Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1

Ha reum Lee, Sun Young Yoon, Ho Bum Kang, Sunyoung Park, Kyung Eun Kim, Young Hoon Cho, Seonghan Kim, Chul woo Kim, Byung Joo Cho, Wang Jae Lee, Sa Ik Bang, Hyunjeong Park, Daeho Cho

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Thymosin beta 4 (Tβ4), which is the major G-actin sequestering protein, has been shown to have ubiquitous distribution and multiple biological activities. However, Tβ4's functions in relation to natural killer (NK) cells are still unknown. In this study, we show that synthetic Tβ4 peptide increases NK cell cytotoxicity mediated by intercellular adhesion molecule-1 (ICAM-1) through the secretion of cytolytic granules to target cells. This suggests that Tβ4 is a key activator of NK cell cytotoxicity.

Original languageEnglish
Pages (from-to)72-76
Number of pages5
JournalImmunology Letters
Issue number1
Publication statusPublished - 2009 Mar 24
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the SRC program (Research Center for Women's Diseases, R11-2005-017-04002-0) of Korea Science Engineering Foundation (KOSEF), the Tumor Immunity Medical Research Center (TIMRC) at Seoul National University College of Medicine, and the Korea Research Foundation Grant funded by the Korean Government (KRF-2008-314-E00092).


  • ICAM-1
  • NK cell cytotoxicity
  • Thymosin beta 4

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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