Time-dependent bioaccumulation of distinct rod-type TiO2 nanoparticles: Comparison by crystalline phase

Eun Jung Park, Gwang Hee Lee, Cheolho Yoon, Min Sung Kang, Soo Nam Kim, Myung Haing Cho, Jae Ho Kim, Dong Wan Kim

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


A complete understanding of the interaction between nanoparticles and biological systems, including nanoparticle uptake and distribution and the biological responses, could guide the design of safer and more effective nanoparticles than those currently available. In this study, we compared the distribution in mice over time of two rod-type titanium dioxide nanoparticles (TiNPs) that feature distinct phases, anatase (ATO) and brookite (BTO). Surface areas of BTO and ATO were estimated to be 102 and 268m2g-1, respectively, and negative charge on the surface of ATO was higher than that of BTO in deionized water. Both TiNPs were rapidly distributed into tissues after injection. At 4weeks after injection, both TiNPs were maximally accumulated in the spleen, followed by the liver, but the total accumulation of ATO in tissues measured in this study was more than that of BTO. Moreover, the cellular antioxidant function was similar although the levels of Ti measured in tissues were distinct between the two TiNPs. Based on these results, we suggest that the fate of TiNPs in the body may differ according to the size and surface charge of the TiNPs even when their shape is the same.

Original languageEnglish
Pages (from-to)1265-1270
Number of pages6
JournalJournal of Applied Toxicology
Issue number11
Publication statusPublished - 2014 Nov 1


  • Distribution
  • Nanorods
  • Surface area
  • Surface charge
  • Titanium dioxide nanoparticles
  • Trace elements

ASJC Scopus subject areas

  • Toxicology


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