Tissue inhibitor of metalloproteinase 1 regulates resistance to infection

Marie Mei Lee, Bong June Yoon, Keith Osiewicz, Michael Preston, Brian Bundy, Anna M. Van Heeckeren, Zena Werb, Paul D. Soloway

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


Tissue inhibitor of meialloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.

Original languageEnglish
Pages (from-to)661-665
Number of pages5
JournalInfection and Immunity
Issue number1
Publication statusPublished - 2005 Jan
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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