Tissue inhibitor of metalloproteinase 1 regulates resistance to infection

Marie Mei Lee; Bong June Yoon; Keith Osiewicz; Michael Preston; Brian Bundy; Anna M. Van Heeckeren; Zena Werb; Paul D. Soloway

doi:10.1128/IAI.73.1.661-665.2005

Tissue inhibitor of metalloproteinase 1 regulates resistance to infection

Marie Mei Lee
, Bong June Yoon
, Keith Osiewicz
, Michael Preston
, Brian Bundy
, Anna M. Van Heeckeren
, Zena Werb
, Paul D. Soloway^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

Tissue inhibitor of meialloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.

Original language	English
Pages (from-to)	661-665
Number of pages	5
Journal	Infection and Immunity
Volume	73
Issue number	1
DOIs	https://doi.org/10.1128/IAI.73.1.661-665.2005
Publication status	Published - 2005 Jan
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.73.1.661-665.2005

Cite this

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title = "Tissue inhibitor of metalloproteinase 1 regulates resistance to infection",

abstract = "Tissue inhibitor of meialloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.",

author = "Lee, \{Marie Mei\} and Yoon, \{Bong June\} and Keith Osiewicz and Michael Preston and Brian Bundy and \{Van Heeckeren\}, \{Anna M.\} and Zena Werb and Soloway, \{Paul D.\}",

year = "2005",

month = jan,

doi = "10.1128/IAI.73.1.661-665.2005",

language = "English",

volume = "73",

pages = "661--665",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Tissue inhibitor of metalloproteinase 1 regulates resistance to infection

AU - Lee, Marie Mei

AU - Yoon, Bong June

AU - Osiewicz, Keith

AU - Preston, Michael

AU - Bundy, Brian

AU - Van Heeckeren, Anna M.

AU - Werb, Zena

AU - Soloway, Paul D.

PY - 2005/1

Y1 - 2005/1

N2 - Tissue inhibitor of meialloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.

AB - Tissue inhibitor of meialloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.

UR - https://www.scopus.com/pages/publications/11144262076

U2 - 10.1128/IAI.73.1.661-665.2005

DO - 10.1128/IAI.73.1.661-665.2005

M3 - Article

C2 - 15618213

AN - SCOPUS:11144262076

SN - 0019-9567

VL - 73

SP - 661

EP - 665

JO - Infection and Immunity

JF - Infection and Immunity

IS - 1

ER -

Tissue inhibitor of metalloproteinase 1 regulates resistance to infection

Abstract

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ASJC Scopus subject areas

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