Toluene induces early growth response-1 dependent thymic stromal lymphopoietin expression in human keratinocytes

Hana Lee; Jae Beom Park; Hyu Cheol Bae; Woo In Ryu; Jung Jin Shin; Sang Wook Son

doi:10.1007/s13273-016-0032-z

Toluene induces early growth response-1 dependent thymic stromal lymphopoietin expression in human keratinocytes

Hana Lee, Jae Beom Park, Hyu Cheol Bae, Woo In Ryu, Jung Jin Shin, Sang Wook Son

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Volatile organic compounds (VOCs) can be an important environmental risk factor in the development and/or aggravation of atopic dermatitis (AD). In a several studies to evaluate the clinical effects of air pollution including VOCs on skin symptoms in AD patients. Although these accumulated data shows an association between exposure to VOCs and aggravation of AD, the molecular effects of VOCs on the aggravation of AD is still not clear. The present study demonstrates increases of thymic stromal lymphopoietin (TSLP) in keratinocytes following exposure to toluene. We further investigated the regulatory mechanisms of toluene-induced TSLP expression in human keratinocytes. Toluene induces early growth response-1 (Egr-1) protein expression in human keratinocytes. Moreover, treatment of Egr-1 siRNA abolished toluene-induced TSLP protein expression. Taken together, these findings suggest that in human keratinocytes, the up-regulation of TSLP by toluene is induced through an Egr-1 dependent mechanism.

Original language	English
Pages (from-to)	273-279
Number of pages	7
Journal	Molecular and Cellular Toxicology
Volume	12
Issue number	3
DOIs	https://doi.org/10.1007/s13273-016-0032-z
Publication status	Published - 2016 Sept 1

Bibliographical note

Publisher Copyright:
© 2016, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Science+Business Media Dordrecht.

Keywords

Atopic dermatitis
Early growth response-1
Thymic stromal lymphopoietin
Volatile organic compound

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
Pharmacology, Toxicology and Pharmaceutics(all)
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Toluene induces early growth response-1 dependent thymic stromal lymphopoietin expression in human keratinocytes",

abstract = "Volatile organic compounds (VOCs) can be an important environmental risk factor in the development and/or aggravation of atopic dermatitis (AD). In a several studies to evaluate the clinical effects of air pollution including VOCs on skin symptoms in AD patients. Although these accumulated data shows an association between exposure to VOCs and aggravation of AD, the molecular effects of VOCs on the aggravation of AD is still not clear. The present study demonstrates increases of thymic stromal lymphopoietin (TSLP) in keratinocytes following exposure to toluene. We further investigated the regulatory mechanisms of toluene-induced TSLP expression in human keratinocytes. Toluene induces early growth response-1 (Egr-1) protein expression in human keratinocytes. Moreover, treatment of Egr-1 siRNA abolished toluene-induced TSLP protein expression. Taken together, these findings suggest that in human keratinocytes, the up-regulation of TSLP by toluene is induced through an Egr-1 dependent mechanism.",

keywords = "Atopic dermatitis, Early growth response-1, Thymic stromal lymphopoietin, Volatile organic compound",

author = "Hana Lee and Park, {Jae Beom} and Bae, {Hyu Cheol} and Ryu, {Woo In} and Shin, {Jung Jin} and Son, {Sang Wook}",

note = "Publisher Copyright: {\textcopyright} 2016, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Science+Business Media Dordrecht.",

year = "2016",

month = sep,

day = "1",

doi = "10.1007/s13273-016-0032-z",

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T1 - Toluene induces early growth response-1 dependent thymic stromal lymphopoietin expression in human keratinocytes

AU - Lee, Hana

AU - Park, Jae Beom

AU - Bae, Hyu Cheol

AU - Ryu, Woo In

AU - Shin, Jung Jin

AU - Son, Sang Wook

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Volatile organic compounds (VOCs) can be an important environmental risk factor in the development and/or aggravation of atopic dermatitis (AD). In a several studies to evaluate the clinical effects of air pollution including VOCs on skin symptoms in AD patients. Although these accumulated data shows an association between exposure to VOCs and aggravation of AD, the molecular effects of VOCs on the aggravation of AD is still not clear. The present study demonstrates increases of thymic stromal lymphopoietin (TSLP) in keratinocytes following exposure to toluene. We further investigated the regulatory mechanisms of toluene-induced TSLP expression in human keratinocytes. Toluene induces early growth response-1 (Egr-1) protein expression in human keratinocytes. Moreover, treatment of Egr-1 siRNA abolished toluene-induced TSLP protein expression. Taken together, these findings suggest that in human keratinocytes, the up-regulation of TSLP by toluene is induced through an Egr-1 dependent mechanism.

AB - Volatile organic compounds (VOCs) can be an important environmental risk factor in the development and/or aggravation of atopic dermatitis (AD). In a several studies to evaluate the clinical effects of air pollution including VOCs on skin symptoms in AD patients. Although these accumulated data shows an association between exposure to VOCs and aggravation of AD, the molecular effects of VOCs on the aggravation of AD is still not clear. The present study demonstrates increases of thymic stromal lymphopoietin (TSLP) in keratinocytes following exposure to toluene. We further investigated the regulatory mechanisms of toluene-induced TSLP expression in human keratinocytes. Toluene induces early growth response-1 (Egr-1) protein expression in human keratinocytes. Moreover, treatment of Egr-1 siRNA abolished toluene-induced TSLP protein expression. Taken together, these findings suggest that in human keratinocytes, the up-regulation of TSLP by toluene is induced through an Egr-1 dependent mechanism.

KW - Atopic dermatitis

KW - Early growth response-1

KW - Thymic stromal lymphopoietin

KW - Volatile organic compound

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U2 - 10.1007/s13273-016-0032-z

DO - 10.1007/s13273-016-0032-z

M3 - Article

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SN - 1738-642X

VL - 12

SP - 273

EP - 279

JO - Molecular and Cellular Toxicology

JF - Molecular and Cellular Toxicology

IS - 3

ER -

Toluene induces early growth response-1 dependent thymic stromal lymphopoietin expression in human keratinocytes

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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