Topical administration of cyclosporin A in a solid lipid nanoparticle formulation

Sung Tae Kim; Dong Jin Jang; Jong Hyo Kim; Joo Yeon Park; Ji Soo Lim; So Yeon Lee; Kyung Mi Lee; Soo Jeong Lim; Chong Kook Kim

doi:10.1691/ph.2009.8373

Topical administration of cyclosporin A in a solid lipid nanoparticle formulation

Sung Tae Kim, Dong Jin Jang, Jong Hyo Kim, Joo Yeon Park, Ji Soo Lim, So Yeon Lee, Kyung Mi Lee, Soo Jeong Lim, Chong Kook Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Cyclosporin A (CsA)-loaded solid lipid nanoparticles (SLN) were developed for improved skin penetration. CsA-loaded SLN, prepared using a hot homogenization method, were nano-sized (about 73 nm) with a slightly negative surface charge (about -16 mV) and stable under physiological conditions regardless of CsA incorporation. In vitro permeation studies using murine skin mounted in the Franztype vertical diffusion assembly revealed that the skin permeation efficiency of CsA-loaded SLN was 2-fold higher than that of CsA-oil mixture in viable skin. Furthermore, topically administered CsAloaded SLN relieved symptoms of atopic dermatitis (AD) in an in vivo murine model of AD by decreasing the T helper (Th) 2 cell-related cytokines interleukin (IL)-4 and -5. These results suggest that SLN are effective drug carriers for topical delivery and that CsA-loaded SLN can be therapeutically applied in allergy-related skin disorders.

Original language	English
Pages (from-to)	510-514
Number of pages	5
Journal	Pharmazie
Volume	64
Issue number	8
DOIs	https://doi.org/10.1691/ph.2009.8373
Publication status	Published - 2009 Aug

ASJC Scopus subject areas

Pharmaceutical Science

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10.1691/ph.2009.8373

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title = "Topical administration of cyclosporin A in a solid lipid nanoparticle formulation",

abstract = "Cyclosporin A (CsA)-loaded solid lipid nanoparticles (SLN) were developed for improved skin penetration. CsA-loaded SLN, prepared using a hot homogenization method, were nano-sized (about 73 nm) with a slightly negative surface charge (about -16 mV) and stable under physiological conditions regardless of CsA incorporation. In vitro permeation studies using murine skin mounted in the Franztype vertical diffusion assembly revealed that the skin permeation efficiency of CsA-loaded SLN was 2-fold higher than that of CsA-oil mixture in viable skin. Furthermore, topically administered CsAloaded SLN relieved symptoms of atopic dermatitis (AD) in an in vivo murine model of AD by decreasing the T helper (Th) 2 cell-related cytokines interleukin (IL)-4 and -5. These results suggest that SLN are effective drug carriers for topical delivery and that CsA-loaded SLN can be therapeutically applied in allergy-related skin disorders.",

author = "Kim, {Sung Tae} and Jang, {Dong Jin} and Kim, {Jong Hyo} and Park, {Joo Yeon} and Lim, {Ji Soo} and Lee, {So Yeon} and Lee, {Kyung Mi} and Lim, {Soo Jeong} and Kim, {Chong Kook}",

year = "2009",

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doi = "10.1691/ph.2009.8373",

language = "English",

volume = "64",

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AU - Kim, Sung Tae

AU - Jang, Dong Jin

AU - Kim, Jong Hyo

AU - Park, Joo Yeon

AU - Lim, Ji Soo

AU - Lee, So Yeon

AU - Lee, Kyung Mi

AU - Lim, Soo Jeong

AU - Kim, Chong Kook

PY - 2009/8

Y1 - 2009/8

N2 - Cyclosporin A (CsA)-loaded solid lipid nanoparticles (SLN) were developed for improved skin penetration. CsA-loaded SLN, prepared using a hot homogenization method, were nano-sized (about 73 nm) with a slightly negative surface charge (about -16 mV) and stable under physiological conditions regardless of CsA incorporation. In vitro permeation studies using murine skin mounted in the Franztype vertical diffusion assembly revealed that the skin permeation efficiency of CsA-loaded SLN was 2-fold higher than that of CsA-oil mixture in viable skin. Furthermore, topically administered CsAloaded SLN relieved symptoms of atopic dermatitis (AD) in an in vivo murine model of AD by decreasing the T helper (Th) 2 cell-related cytokines interleukin (IL)-4 and -5. These results suggest that SLN are effective drug carriers for topical delivery and that CsA-loaded SLN can be therapeutically applied in allergy-related skin disorders.

AB - Cyclosporin A (CsA)-loaded solid lipid nanoparticles (SLN) were developed for improved skin penetration. CsA-loaded SLN, prepared using a hot homogenization method, were nano-sized (about 73 nm) with a slightly negative surface charge (about -16 mV) and stable under physiological conditions regardless of CsA incorporation. In vitro permeation studies using murine skin mounted in the Franztype vertical diffusion assembly revealed that the skin permeation efficiency of CsA-loaded SLN was 2-fold higher than that of CsA-oil mixture in viable skin. Furthermore, topically administered CsAloaded SLN relieved symptoms of atopic dermatitis (AD) in an in vivo murine model of AD by decreasing the T helper (Th) 2 cell-related cytokines interleukin (IL)-4 and -5. These results suggest that SLN are effective drug carriers for topical delivery and that CsA-loaded SLN can be therapeutically applied in allergy-related skin disorders.

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DO - 10.1691/ph.2009.8373

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SP - 510

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JF - Die Pharmazie

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Topical administration of cyclosporin A in a solid lipid nanoparticle formulation

Abstract

ASJC Scopus subject areas

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