TY - JOUR
T1 - Topical methylene blue nanoformulation for the photodynamic therapy of acne vulgaris
AU - Lee, Yong Deok
AU - Yang, Jin Kyoung
AU - Han, Sunmi
AU - Kim, Bo Ri
AU - Shin, Jung Won
AU - Bang, Joona
AU - Kim, Sehoon
N1 - Funding Information:
This work was supported by the research fund from D.R.Nano Co., Ltd.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2023/5
Y1 - 2023/5
N2 - Acne vulgaris is a common skin disease caused by multifactorial reasons involving excessive sebum secretion and inflammation by Cutibacterium acnes (C. acnes). Various conventional therapies are available for the treatment of acne vulgaris; however, topical photodynamic therapy (PDT) has attracted much attention because of its great potential for sebum-reducing, anti-inflammatory, and antimicrobial activities. Although 5-aminolevulinic acid (ALA) has been broadly used as a photosensitizer for topical PDT, it has several limitations such as long incubation time, pain, and post-inflammatory hyperpigmentation. Here, we report a biocompatible nanoformulation consisting of methylene blue and salicylic acid (MBSD), as a potent PDT and acne therapeutics, enclosed within oleic acid. Photoactivated MBSD showed antimicrobial activity against C. acnes along with long-term stability. When 24 patients with acne were treated with MBSD and light irradiation 5 times at 1-week intervals, MBSD-based PDT exhibited a remarkable reduction in acne lesions and sebum production. In addition, the therapeutic procedure was painless and safe, without any adverse events. Therefore, MBSD is a promising topical PDT agent for biocompatible, safe, and effective acne treatment.
AB - Acne vulgaris is a common skin disease caused by multifactorial reasons involving excessive sebum secretion and inflammation by Cutibacterium acnes (C. acnes). Various conventional therapies are available for the treatment of acne vulgaris; however, topical photodynamic therapy (PDT) has attracted much attention because of its great potential for sebum-reducing, anti-inflammatory, and antimicrobial activities. Although 5-aminolevulinic acid (ALA) has been broadly used as a photosensitizer for topical PDT, it has several limitations such as long incubation time, pain, and post-inflammatory hyperpigmentation. Here, we report a biocompatible nanoformulation consisting of methylene blue and salicylic acid (MBSD), as a potent PDT and acne therapeutics, enclosed within oleic acid. Photoactivated MBSD showed antimicrobial activity against C. acnes along with long-term stability. When 24 patients with acne were treated with MBSD and light irradiation 5 times at 1-week intervals, MBSD-based PDT exhibited a remarkable reduction in acne lesions and sebum production. In addition, the therapeutic procedure was painless and safe, without any adverse events. Therefore, MBSD is a promising topical PDT agent for biocompatible, safe, and effective acne treatment.
KW - Acne vulgaris
KW - Methylene blue
KW - Nanoformulation
KW - Photodynamic therapy
KW - Salicylic acid
UR - http://www.scopus.com/inward/record.url?scp=85141992579&partnerID=8YFLogxK
U2 - 10.1007/s00403-022-02464-7
DO - 10.1007/s00403-022-02464-7
M3 - Article
C2 - 36376760
AN - SCOPUS:85141992579
SN - 0340-3696
VL - 315
SP - 885
EP - 893
JO - Archives of Dermatological Research
JF - Archives of Dermatological Research
IS - 4
ER -