Topological graph kernel on multiple thresholded functional connectivity networks for mild cognitive impairment classification

Biao Jie, Daoqiang Zhang, Chong Yaw Wee, Dinggang Shen

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)


Recently, brain connectivity networks have been used for classification of Alzheimer's disease and mild cognitive impairment (MCI) from normal controls (NC). In typical connectivity-networks-based classification approaches, local measures of connectivity networks are first extracted from each region-of-interest as network features, which are then concatenated into a vector for subsequent feature selection and classification. However, some useful structural information of network, especially global topological information, may be lost in this type of approaches. To address this issue, in this article, we propose a connectivity-networks-based classification framework to identify accurately the MCI patients from NC. The core of the proposed method involves the use of a new graph-kernel-based approach to measure directly the topological similarity between connectivity networks. We evaluate our method on functional connectivity networks of 12 MCI and 25 NC subjects. The experimental results show that our proposed method achieves a classification accuracy of 91.9%, a sensitivity of 100.0%, a balanced accuracy of 94.0%, and an area under receiver operating characteristic curve of 0.94, demonstrating a great potential in MCI classification, based on connectivity networks. Further connectivity analysis indicates that the connectivity of the selected brain regions is different between MCI patients and NC, that is, MCI patients show reduced functional connectivity compared with NC, in line with the findings reported in the existing studies.

Original languageEnglish
Pages (from-to)2876-2897
Number of pages22
JournalHuman Brain Mapping
Issue number7
Publication statusPublished - 2014 Jul


  • Alzheimer's disease
  • Functional connectivity network
  • Graph kernel
  • Mild cognitive impairment
  • Multiple thresholds

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology


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