Abstract
A new protocol for the synthesis of 2,2′-bisindole-3-acetic acid derivatives from aldimines derived from 2-aminocinnamic acid derivatives and indole-2-carboxaldehyde was developed via a cyanide-catalyzed imino-Stetter reaction. With this protocol, the divergent total syntheses of arcyriaflavin A, a representative indolocarbazole natural product, and calothrixin B, a representative indolo[3,2-j]phenanthridine natural product, were completed using a 2,2′-bisindole-3-acetic acid derivative as the common intermediate.
Original language | English |
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Pages (from-to) | 2785-2788 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 19 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2017 Jun 2 |
Bibliographical note
Publisher Copyright:© 2017 American Chemical Society.
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry