Abstract
The total synthesis of iheyamine A from readily available ethyl 2-aminocinnamate and 5-methoxyindole-2-carboxaldehyde is described. The cyanide-catalyzed imino-Stetter reaction of an aldimine derived from ethyl 2-aminocinnamate and 5-methoxyindole-2-carboxaldehyde provided the desired unsymmetrical 2,2′-bisindole-3-acetic acid derivative. The subsequent introduction of an amino group at the C-3′ position, followed by the formation of the azepine ring, completed the total synthesis of iheyamine A.
Original language | English |
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Pages (from-to) | 8149-8156 |
Number of pages | 8 |
Journal | Journal of Organic Chemistry |
Volume | 85 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2020 Jun 19 |
Bibliographical note
Publisher Copyright:Copyright © 2020 American Chemical Society.
ASJC Scopus subject areas
- Organic Chemistry