TY - JOUR
T1 - Toxicity Evaluation by Single and Repeated Administration of Yeast Hydrolysate DNF-10
AU - Ahn, Yejin
AU - Kim, Singeun
AU - Suh, Hyung Joo
AU - Jung, Eun Young
N1 - Publisher Copyright:
© 2021 Korean Society of Food Science and Nutrition. All rights reserved.
PY - 2021
Y1 - 2021
N2 - This study aimed at investigating the acute and subacute oral toxicity of yeast hydrolysate (DNF-10) in Sprague-Dawley rats. To determine the acute toxicity of DNF-10, it was orally administered to rats at a dose of 5,000 mg/kg. Furthermore, to determine subacute toxicity of DNF-10, it was orally administered to female and male rats at a dose of 1,000 mg/kg for 90 days. In the acute toxicity test, the experimental group did not show changes in body and organ weights compared to the corresponding weights in the control group. When compared to female controls, the DNF-10-treated female rats showed decreased red blood cell counts, haemoglobin, and total bilirubin levels; however, the parameters remained within the normal range. In the subacute toxicity test, DNF-10 administration significantly reduced body weight among male rats, which appears attributable to the anti-obesity effect of the compound. In the experimental groups, significant differences in some haematological parameters were considered as non-toxic because the results were within the normal range. These results suggest that DNF-10 is safe and non-toxic at single doses (5,000 mg/kg) and repeated doses (1,000 mg/kg).
AB - This study aimed at investigating the acute and subacute oral toxicity of yeast hydrolysate (DNF-10) in Sprague-Dawley rats. To determine the acute toxicity of DNF-10, it was orally administered to rats at a dose of 5,000 mg/kg. Furthermore, to determine subacute toxicity of DNF-10, it was orally administered to female and male rats at a dose of 1,000 mg/kg for 90 days. In the acute toxicity test, the experimental group did not show changes in body and organ weights compared to the corresponding weights in the control group. When compared to female controls, the DNF-10-treated female rats showed decreased red blood cell counts, haemoglobin, and total bilirubin levels; however, the parameters remained within the normal range. In the subacute toxicity test, DNF-10 administration significantly reduced body weight among male rats, which appears attributable to the anti-obesity effect of the compound. In the experimental groups, significant differences in some haematological parameters were considered as non-toxic because the results were within the normal range. These results suggest that DNF-10 is safe and non-toxic at single doses (5,000 mg/kg) and repeated doses (1,000 mg/kg).
KW - Acute toxicity
KW - Saccharomyces cerevisiae
KW - Subacute toxicity
KW - Yeast hydrolysate
UR - http://www.scopus.com/inward/record.url?scp=85104979285&partnerID=8YFLogxK
U2 - 10.3746/PNF.2021.26.1.75
DO - 10.3746/PNF.2021.26.1.75
M3 - Article
AN - SCOPUS:85104979285
SN - 2287-1098
VL - 26
SP - 75
EP - 81
JO - Preventive Nutrition and Food Science
JF - Preventive Nutrition and Food Science
IS - 1
ER -