Transcriptome analysis of Shank3-overexpressing mice reveals unique molecular changes in the hypothalamus 06 Biological Sciences 0604 Genetics

Keyphrases

• Overexpressing 100%
• Hypothalamus 100%
• Transcriptome Analysis 100%
• Molecular Changes 100%
• SHANK3 100%
• Biological Sciences 100%
• Striatum 41%
• Transgenic Mice 33%
• Medial Prefrontal Cortex (mPFC) 33%
• MRNA Expression 16%
• Protein Expression 16%
• Brain Regions 16%
• Transgenic 16%
• Upregulated Genes 8%
• Hippocampus 8%
• Wild Mice 8%
• Energy Intake 8%
• Prefrontal Cortex 8%
• Neuropsychiatric Disorders 8%
• Differentially Expressed Genes 8%
• Mutant Mice 8%
• Downregulated Genes 8%
• Knock 8%
• RNA Sequencing (RNA-seq) 8%
• RNA-seq Analysis 8%
• Synaptic Dysfunction 8%
• Ankyrin Repeat 8%
• Ventral Tegmental Area 8%
• Gene Set Enrichment Analysis 8%
• Energy Expenditure 8%
• Neurodevelopmental Disorders 8%
• SHANK3 Gene 8%

Biochemistry, Genetics and Molecular Biology

• Transgenic Mouse 100%
• Genetics 100%
• Gene Expression Profiling 100%
• Transgenics 50%
• Protein Expression 50%
• RNA Sequence 50%
• Messenger RNA 50%
• Body Weight 25%
• Wild Type Mouse 25%
• Mouse Mutant 25%
• Ankyrin Repeat 25%
• Ankyrin 25%
• Gene Set Enrichment Analysis 25%
• SHANK3 25%

Neuroscience

• Hypothalamus 100%
• Transcriptome 100%
• Striatum 55%
• Prefrontal Cortex 55%
• Protein Expression 22%
• Ribosome 22%
• RNA Sequence 22%
• Messenger RNA 22%
• Hippocampus 11%
• Ventral Tegmental Area 11%
• Ankyrin 11%
• Neurodevelopmental Disorder 11%