Transcriptome analysis reveals the ahr, smad2/3, and hif-1α pathways as the mechanism of ochratoxin a toxicity in kidney cells

Keyphrases

• Kidney Cells 100%
• Smad2 100%
• Hypoxia-inducible factor-1α (HIF-1α) 100%
• Transcriptome Analysis 100%
• Ochratoxin A 100%
• Small Interfering RNA (siRNA) 42%
• Caspase-3 42%
• Kidney Injury molecule-1 (KIM-1) 42%
• Apoptosis 28%
• Epithelial-mesenchymal Transition 28%
• RNA-seq Analysis 28%
• HK-2 Cells 28%
• Transcription Factor 14%
• Hypoxia 14%
• Kidney 14%
• Kidney Toxicity 14%
• Kidney Injury 14%
• Fibronectin 14%
• Renal Toxicity 14%
• E-cadherin 14%
• Renal Tubular Epithelial Cells 14%
• Differentially Expressed Genes 14%
• Metabolic Pathway 14%
• Gene Expression Pattern 14%
• Xenobiotic Metabolism 14%
• Real-time PCR Analysis 14%
• Mesenchymal-epithelial Transition Factor 14%
• RNA Sequencing (RNA-seq) 14%
• Target Organ 14%
• Food Consumed 14%
• Mycotoxins 14%
• Apoptosis Markers 14%
• Global Concern 14%
• HIF-1 Signaling Pathway 14%
• RNA Transcriptome 14%
• Transition Metabolism 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Transcriptome 100%
• Ochratoxin 100%
• Small Interfering RNA 42%
• Kidney Injury Molecule 1 42%
• Caspase 3 42%
• Nephrotoxicity 28%
• Kidney Injury 14%
• Fibronectin 14%
• Hypoxia 14%
• Xenobiotic Metabolism 14%
• Uvomorulin 14%
• Mycotoxin 14%
• RNA-Sequencing 14%
• Smad2 Protein 14%