Transcriptomic approaches to toxicity assessment

Dal Woong Choi, Woonun Jung, Il Je Cho, Min Sung Joo, Chan Gyu Lee, Sang Woo Lim, Sang Geon Kim

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    ‘Omics’ technologies, such as the study of genomes (‘genomics’), proteomes (‘proteomics’) and metabolites (‘metabolomics’), are widely applied in a diverse range of biological disciplines. Furthermore, the ready availability of entire genome sequences from humans and many other organisms has resulted in numerous studies to understand gene functions (1). In gene function studies, gene expression is generally viewed as the expression of transcripts that encode the fi nal product of proteins. Transcripts globally expressed from the genome are called the transcriptome: the mRNAs produced as a result of transcription from individual genes are called transcripts, while the entire array of mRNAs transcribed from all genes (i.e., genome) is called the transcriptome; the study of transcriptomes is called transcriptomics (2). The fi nal protein products globally expressed from genomes are called proteomes (3). The transcriptomes and proteomes are collectively referred to as expressomes, and global assessment of expressomes is called expressomics.

    Original languageEnglish
    Title of host publicationKidney
    Subtitle of host publicationToxicological Assessment
    PublisherCRC Press
    Pages21-41
    Number of pages21
    ISBN (Electronic)9781466588127
    ISBN (Print)9781466588110
    DOIs
    Publication statusPublished - 2013 Jan 1

    Bibliographical note

    Publisher Copyright:
    © 2014 by Taylor & Francis Group, LLC.

    ASJC Scopus subject areas

    • General Medicine

    Fingerprint

    Dive into the research topics of 'Transcriptomic approaches to toxicity assessment'. Together they form a unique fingerprint.

    Cite this