Transferrin induces interleukin-18 expression in chronic myeloid leukemia cell line, K-562

Sunyoung Park; Tae Sung Kim; Cherlhyun Kim; Seonghan Kim; Sa Ik Bang; Hyunjeong Park; Dae Ho Cho

doi:10.1016/j.leukres.2008.08.001

Transferrin induces interleukin-18 expression in chronic myeloid leukemia cell line, K-562

Sunyoung Park, Tae Sung Kim, Cherlhyun Kim, Seonghan Kim, Sa Ik Bang, Hyunjeong Park, Dae Ho Cho

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Transferrin is an iron carrier protein involved in iron uptake and the regulation of cell growth. Although highly proliferative cells express transferrin and its receptor, little is known about the role of transferrin in the cellular response to cytokine production. The non-iron-bound form of transferrin (apo-transferrin) was administered to human chronic myeloid leukemia cell line, K-562 cells to assess whether it could induce interleukin-18 (IL-18). Apo-transferrin enhanced IL-18 mRNA and protein and, moreover, IL-18 secretion was increased by treatment with apo-transferrin. In conclusion, apo-transferrin regulates IL-18 expression and we suggest that it is involved in cytokine production.

Original language	English
Pages (from-to)	315-320
Number of pages	6
Journal	Leukemia Research
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/j.leukres.2008.08.001
Publication status	Published - 2009 Feb

Bibliographical note

Funding Information:
This work was supported by the Korea Science & Engineering Foundation (KOSEF) through the Research Center for Women’s Disease (RCWD) at Sookmyung Women’s University, a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (A050569) and Seoul Research and Business Development Program (10582).

Keywords

Apo-transferrin
Interleukin-18 (IL-18)
Leukemia
Proliferation
Transferrin

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2008.08.001

Cite this

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title = "Transferrin induces interleukin-18 expression in chronic myeloid leukemia cell line, K-562",

abstract = "Transferrin is an iron carrier protein involved in iron uptake and the regulation of cell growth. Although highly proliferative cells express transferrin and its receptor, little is known about the role of transferrin in the cellular response to cytokine production. The non-iron-bound form of transferrin (apo-transferrin) was administered to human chronic myeloid leukemia cell line, K-562 cells to assess whether it could induce interleukin-18 (IL-18). Apo-transferrin enhanced IL-18 mRNA and protein and, moreover, IL-18 secretion was increased by treatment with apo-transferrin. In conclusion, apo-transferrin regulates IL-18 expression and we suggest that it is involved in cytokine production.",

keywords = "Apo-transferrin, Interleukin-18 (IL-18), Leukemia, Proliferation, Transferrin",

author = "Sunyoung Park and Kim, {Tae Sung} and Cherlhyun Kim and Seonghan Kim and Bang, {Sa Ik} and Hyunjeong Park and Cho, {Dae Ho}",

note = "Funding Information: This work was supported by the Korea Science & Engineering Foundation (KOSEF) through the Research Center for Women{\textquoteright}s Disease (RCWD) at Sookmyung Women{\textquoteright}s University, a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (A050569) and Seoul Research and Business Development Program (10582).",

year = "2009",

month = feb,

doi = "10.1016/j.leukres.2008.08.001",

language = "English",

volume = "33",

pages = "315--320",

journal = "Leukemia Research",

issn = "0145-2126",

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number = "2",

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T1 - Transferrin induces interleukin-18 expression in chronic myeloid leukemia cell line, K-562

AU - Park, Sunyoung

AU - Kim, Tae Sung

AU - Kim, Cherlhyun

AU - Kim, Seonghan

AU - Bang, Sa Ik

AU - Park, Hyunjeong

AU - Cho, Dae Ho

N1 - Funding Information: This work was supported by the Korea Science & Engineering Foundation (KOSEF) through the Research Center for Women’s Disease (RCWD) at Sookmyung Women’s University, a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (A050569) and Seoul Research and Business Development Program (10582).

PY - 2009/2

Y1 - 2009/2

N2 - Transferrin is an iron carrier protein involved in iron uptake and the regulation of cell growth. Although highly proliferative cells express transferrin and its receptor, little is known about the role of transferrin in the cellular response to cytokine production. The non-iron-bound form of transferrin (apo-transferrin) was administered to human chronic myeloid leukemia cell line, K-562 cells to assess whether it could induce interleukin-18 (IL-18). Apo-transferrin enhanced IL-18 mRNA and protein and, moreover, IL-18 secretion was increased by treatment with apo-transferrin. In conclusion, apo-transferrin regulates IL-18 expression and we suggest that it is involved in cytokine production.

AB - Transferrin is an iron carrier protein involved in iron uptake and the regulation of cell growth. Although highly proliferative cells express transferrin and its receptor, little is known about the role of transferrin in the cellular response to cytokine production. The non-iron-bound form of transferrin (apo-transferrin) was administered to human chronic myeloid leukemia cell line, K-562 cells to assess whether it could induce interleukin-18 (IL-18). Apo-transferrin enhanced IL-18 mRNA and protein and, moreover, IL-18 secretion was increased by treatment with apo-transferrin. In conclusion, apo-transferrin regulates IL-18 expression and we suggest that it is involved in cytokine production.

KW - Apo-transferrin

KW - Interleukin-18 (IL-18)

KW - Leukemia

KW - Proliferation

KW - Transferrin

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Transferrin induces interleukin-18 expression in chronic myeloid leukemia cell line, K-562

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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