Transferrin induces interleukin-18 expression in chronic myeloid leukemia cell line, K-562

Sunyoung Park, Tae Sung Kim, Cherlhyun Kim, Seonghan Kim, Sa Ik Bang, Hyunjeong Park, Dae Ho Cho

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Transferrin is an iron carrier protein involved in iron uptake and the regulation of cell growth. Although highly proliferative cells express transferrin and its receptor, little is known about the role of transferrin in the cellular response to cytokine production. The non-iron-bound form of transferrin (apo-transferrin) was administered to human chronic myeloid leukemia cell line, K-562 cells to assess whether it could induce interleukin-18 (IL-18). Apo-transferrin enhanced IL-18 mRNA and protein and, moreover, IL-18 secretion was increased by treatment with apo-transferrin. In conclusion, apo-transferrin regulates IL-18 expression and we suggest that it is involved in cytokine production.

Original languageEnglish
Pages (from-to)315-320
Number of pages6
JournalLeukemia Research
Issue number2
Publication statusPublished - 2009 Feb
Externally publishedYes


  • Apo-transferrin
  • Interleukin-18 (IL-18)
  • Leukemia
  • Proliferation
  • Transferrin

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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