Transferrin saturation concentrations associated with telomeric ageing: A population-based study

Chol Shin; Inkyung Baik

doi:10.1017/S0007114517001696

Transferrin saturation concentrations associated with telomeric ageing: A population-based study

Chol Shin, Inkyung Baik

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

There are limited data on the association between Fe overload and leucocyte telomere length (LTL), known as a useful biomarker of the replicative ageing of cells. The aim of the study was to evaluate associations between Fe-status biomarkers and LTL. A cross-sectional study included 1174 men and women aged 50-79 years who provided blood samples for assays of Fe-status biomarkers including ferritin, transferrin saturation (TSAT), total Fe-binding capacity (TIBC) and relative LTL. They were free of hepatitis, potential infection or Fe deficiency. In multiple linear regression analysis adjusted for potential confounding variables, log-transformed LTL was positively associated with TIBC (adjusted coefficient estimate for its highest quartile: 0·17 (se 0·03), P<0·001) and inversely associated with TSAT (adjusted coefficient estimate for its third and fourth quartiles:-0·09 (se 0·03), P<0·01). These associations were consistent after additional adjustment for serum concentrations of high-sensitivity C-reactive protein, alanine transaminase and aspartate transaminase. In particular, participants with not only abnormally high concentrations (>45 %) but also with high-normal concentrations (35-45 %) of TSAT had shorter LTL compared with those with low-normal concentrations (<30 %) (P<0·05). We also observed that less-active or obese persons with high TSAT concentrations had shorter LTL than others. Our findings that cellular ageing is influenced not only by Fe overload but also by high-normal concentrations of TSAT support the hypothesis regarding the detrimental effects of labile Fe, which has a potent pro-oxidant activity in the body.

Original language	English
Pages (from-to)	1693-1701
Number of pages	9
Journal	British Journal of Nutrition
Volume	117
Issue number	12
DOIs	https://doi.org/10.1017/S0007114517001696
Publication status	Published - 2017 Jun 28

Bibliographical note

Funding Information:
This study was supported by a National Research Foundation of Korea Grant funded by the Korean Government (I. B., NRF-2017R1A2A2A05001380) and a fund (C. S., 2011-E71004-00, 2012-E71005-00, 2013-E71005-00) for research from Korea Centers for Disease Control and Prevention.

Publisher Copyright:
© 2017 The Authors.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

General populations
Iron overload
Iron status
Telomere length
Transferrin saturation

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1017/S0007114517001696

Cite this

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title = "Transferrin saturation concentrations associated with telomeric ageing: A population-based study",

abstract = "There are limited data on the association between Fe overload and leucocyte telomere length (LTL), known as a useful biomarker of the replicative ageing of cells. The aim of the study was to evaluate associations between Fe-status biomarkers and LTL. A cross-sectional study included 1174 men and women aged 50-79 years who provided blood samples for assays of Fe-status biomarkers including ferritin, transferrin saturation (TSAT), total Fe-binding capacity (TIBC) and relative LTL. They were free of hepatitis, potential infection or Fe deficiency. In multiple linear regression analysis adjusted for potential confounding variables, log-transformed LTL was positively associated with TIBC (adjusted coefficient estimate for its highest quartile: 0·17 (se 0·03), P<0·001) and inversely associated with TSAT (adjusted coefficient estimate for its third and fourth quartiles:-0·09 (se 0·03), P<0·01). These associations were consistent after additional adjustment for serum concentrations of high-sensitivity C-reactive protein, alanine transaminase and aspartate transaminase. In particular, participants with not only abnormally high concentrations (>45 %) but also with high-normal concentrations (35-45 %) of TSAT had shorter LTL compared with those with low-normal concentrations (<30 %) (P<0·05). We also observed that less-active or obese persons with high TSAT concentrations had shorter LTL than others. Our findings that cellular ageing is influenced not only by Fe overload but also by high-normal concentrations of TSAT support the hypothesis regarding the detrimental effects of labile Fe, which has a potent pro-oxidant activity in the body.",

keywords = "General populations, Iron overload, Iron status, Telomere length, Transferrin saturation",

author = "Chol Shin and Inkyung Baik",

note = "Funding Information: This study was supported by a National Research Foundation of Korea Grant funded by the Korean Government (I. B., NRF-2017R1A2A2A05001380) and a fund (C. S., 2011-E71004-00, 2012-E71005-00, 2013-E71005-00) for research from Korea Centers for Disease Control and Prevention. Publisher Copyright: {\textcopyright} 2017 The Authors. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

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doi = "10.1017/S0007114517001696",

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T1 - Transferrin saturation concentrations associated with telomeric ageing

T2 - A population-based study

AU - Shin, Chol

AU - Baik, Inkyung

N1 - Funding Information: This study was supported by a National Research Foundation of Korea Grant funded by the Korean Government (I. B., NRF-2017R1A2A2A05001380) and a fund (C. S., 2011-E71004-00, 2012-E71005-00, 2013-E71005-00) for research from Korea Centers for Disease Control and Prevention. Publisher Copyright: © 2017 The Authors. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2017/6/28

Y1 - 2017/6/28

N2 - There are limited data on the association between Fe overload and leucocyte telomere length (LTL), known as a useful biomarker of the replicative ageing of cells. The aim of the study was to evaluate associations between Fe-status biomarkers and LTL. A cross-sectional study included 1174 men and women aged 50-79 years who provided blood samples for assays of Fe-status biomarkers including ferritin, transferrin saturation (TSAT), total Fe-binding capacity (TIBC) and relative LTL. They were free of hepatitis, potential infection or Fe deficiency. In multiple linear regression analysis adjusted for potential confounding variables, log-transformed LTL was positively associated with TIBC (adjusted coefficient estimate for its highest quartile: 0·17 (se 0·03), P<0·001) and inversely associated with TSAT (adjusted coefficient estimate for its third and fourth quartiles:-0·09 (se 0·03), P<0·01). These associations were consistent after additional adjustment for serum concentrations of high-sensitivity C-reactive protein, alanine transaminase and aspartate transaminase. In particular, participants with not only abnormally high concentrations (>45 %) but also with high-normal concentrations (35-45 %) of TSAT had shorter LTL compared with those with low-normal concentrations (<30 %) (P<0·05). We also observed that less-active or obese persons with high TSAT concentrations had shorter LTL than others. Our findings that cellular ageing is influenced not only by Fe overload but also by high-normal concentrations of TSAT support the hypothesis regarding the detrimental effects of labile Fe, which has a potent pro-oxidant activity in the body.

AB - There are limited data on the association between Fe overload and leucocyte telomere length (LTL), known as a useful biomarker of the replicative ageing of cells. The aim of the study was to evaluate associations between Fe-status biomarkers and LTL. A cross-sectional study included 1174 men and women aged 50-79 years who provided blood samples for assays of Fe-status biomarkers including ferritin, transferrin saturation (TSAT), total Fe-binding capacity (TIBC) and relative LTL. They were free of hepatitis, potential infection or Fe deficiency. In multiple linear regression analysis adjusted for potential confounding variables, log-transformed LTL was positively associated with TIBC (adjusted coefficient estimate for its highest quartile: 0·17 (se 0·03), P<0·001) and inversely associated with TSAT (adjusted coefficient estimate for its third and fourth quartiles:-0·09 (se 0·03), P<0·01). These associations were consistent after additional adjustment for serum concentrations of high-sensitivity C-reactive protein, alanine transaminase and aspartate transaminase. In particular, participants with not only abnormally high concentrations (>45 %) but also with high-normal concentrations (35-45 %) of TSAT had shorter LTL compared with those with low-normal concentrations (<30 %) (P<0·05). We also observed that less-active or obese persons with high TSAT concentrations had shorter LTL than others. Our findings that cellular ageing is influenced not only by Fe overload but also by high-normal concentrations of TSAT support the hypothesis regarding the detrimental effects of labile Fe, which has a potent pro-oxidant activity in the body.

KW - General populations

KW - Iron overload

KW - Iron status

KW - Telomere length

KW - Transferrin saturation

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JO - British Journal of Nutrition

JF - British Journal of Nutrition

IS - 12

ER -

Transferrin saturation concentrations associated with telomeric ageing: A population-based study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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