TY - JOUR
T1 - Transformation of Supramolecular Membranes to Vesicles Driven by Spontaneous Gradual Deprotonation on Membrane Surfaces
AU - Seo, Gunhee
AU - Kim, Taeyeon
AU - Shen, Bowen
AU - Kim, Jehan
AU - Kim, Yongju
N1 - Funding Information:
This work was supported by the National Research Foundation of Korea grant funded by the Korea government (MSIT) (NRF-2019R1C1C1008526, NRF-2022R1F1A1075138, and NRF-2022R1A4A1031687), a Korea University grant, and the KU-KIST School Project.
Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.
PY - 2022/9/28
Y1 - 2022/9/28
N2 - The various proteins and asymmetric lipid bilayers present in cell membranes form curvatures, resulting in structural transformations to generate vesicles. Fission and fusion processes between vesicles and cell membranes are reversible in living organisms. Although the transformation of a two-dimensional membrane to a three-dimensional vesicle structure is a common natural phenomenon, the lack of a detailed understanding at the molecular level limits the development of synthetic systems for functional materials. Herein, we report a supramolecular membrane system through donor-acceptor interactions using a π-deficient acceptor and π-rich donor as building blocks. The reduced electrostatic repulsion between ammonium cations and the spontaneously deprotonated neutral amino group induced anisotropic membrane curvature, resulting in membrane fission to form vesicles with a detailed understanding at the molecular level. Furthermore, the reversible transformation of vesicles to membranes upon changing the pH provides a novel synthetic system exhibiting both fission and fusion processes.
AB - The various proteins and asymmetric lipid bilayers present in cell membranes form curvatures, resulting in structural transformations to generate vesicles. Fission and fusion processes between vesicles and cell membranes are reversible in living organisms. Although the transformation of a two-dimensional membrane to a three-dimensional vesicle structure is a common natural phenomenon, the lack of a detailed understanding at the molecular level limits the development of synthetic systems for functional materials. Herein, we report a supramolecular membrane system through donor-acceptor interactions using a π-deficient acceptor and π-rich donor as building blocks. The reduced electrostatic repulsion between ammonium cations and the spontaneously deprotonated neutral amino group induced anisotropic membrane curvature, resulting in membrane fission to form vesicles with a detailed understanding at the molecular level. Furthermore, the reversible transformation of vesicles to membranes upon changing the pH provides a novel synthetic system exhibiting both fission and fusion processes.
UR - http://www.scopus.com/inward/record.url?scp=85138635601&partnerID=8YFLogxK
U2 - 10.1021/jacs.2c06941
DO - 10.1021/jacs.2c06941
M3 - Article
C2 - 36099520
AN - SCOPUS:85138635601
SN - 0002-7863
VL - 144
SP - 17341
EP - 17345
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 38
ER -