Transforming growth factor-β: Expression in normal and pathological conditions

Seong Jin Kim; David Romeo; Young Do Yoo; Keunchil Park

doi:10.1159/000184136

Transforming growth factor-β: Expression in normal and pathological conditions

Seong Jin Kim, David Romeo, Young Do Yoo, Keunchil Park

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Expression of the various isoforms of transforming growth factor-β (TGF-β) is differentially controlled both in vivo and in vitro. Characterization of the molecular mechanisms governing expression of TGF-β isoforms now provides a basis for understanding the selective regulation of expression of the TGF-βs by a variety of factors including oncogenes and tumor suppressor genes. In addition to transcriptional control, data suggest that expression of TGF-βs is also regulated posttranscriptionally. Regulation of TGF-βs by steroids and retinoids appears to involve predominantly posttranscriptional mechanisms. Identification of these mechanisms may contribute to the understanding of the regulatory events controlling cellular proliferation and differentiation by TGF-βs and steroids/retinoids.

Original language	English
Pages (from-to)	5-8
Number of pages	4
Journal	Hormone Research in Paediatrics
Volume	42
Issue number	1-2
DOIs	https://doi.org/10.1159/000184136
Publication status	Published - 1994

Keywords

Expression
Growth factor
Post-transcription
Transcription
Tumor suppressor gene

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000184136

Cite this

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abstract = "Expression of the various isoforms of transforming growth factor-β (TGF-β) is differentially controlled both in vivo and in vitro. Characterization of the molecular mechanisms governing expression of TGF-β isoforms now provides a basis for understanding the selective regulation of expression of the TGF-βs by a variety of factors including oncogenes and tumor suppressor genes. In addition to transcriptional control, data suggest that expression of TGF-βs is also regulated posttranscriptionally. Regulation of TGF-βs by steroids and retinoids appears to involve predominantly posttranscriptional mechanisms. Identification of these mechanisms may contribute to the understanding of the regulatory events controlling cellular proliferation and differentiation by TGF-βs and steroids/retinoids.",

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AU - Park, Keunchil

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AB - Expression of the various isoforms of transforming growth factor-β (TGF-β) is differentially controlled both in vivo and in vitro. Characterization of the molecular mechanisms governing expression of TGF-β isoforms now provides a basis for understanding the selective regulation of expression of the TGF-βs by a variety of factors including oncogenes and tumor suppressor genes. In addition to transcriptional control, data suggest that expression of TGF-βs is also regulated posttranscriptionally. Regulation of TGF-βs by steroids and retinoids appears to involve predominantly posttranscriptional mechanisms. Identification of these mechanisms may contribute to the understanding of the regulatory events controlling cellular proliferation and differentiation by TGF-βs and steroids/retinoids.

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Transforming growth factor-β: Expression in normal and pathological conditions

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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