Transforming growth factor-β: Expression in normal and pathological conditions

Seong Jin Kim; David Romeo; Young Do Yoo; Keunchil Park

doi:10.1159/000184136

Transforming growth factor-β: Expression in normal and pathological conditions

Seong Jin Kim^*
, David Romeo
, Young Do Yoo
, Keunchil Park

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Expression of the various isoforms of transforming growth factor-β (TGF-β) is differentially controlled both in vivo and in vitro. Characterization of the molecular mechanisms governing expression of TGF-β isoforms now provides a basis for understanding the selective regulation of expression of the TGF-βs by a variety of factors including oncogenes and tumor suppressor genes. In addition to transcriptional control, data suggest that expression of TGF-βs is also regulated posttranscriptionally. Regulation of TGF-βs by steroids and retinoids appears to involve predominantly posttranscriptional mechanisms. Identification of these mechanisms may contribute to the understanding of the regulatory events controlling cellular proliferation and differentiation by TGF-βs and steroids/retinoids.

Original language	English
Pages (from-to)	5-8
Number of pages	4
Journal	Hormone Research in Paediatrics
Volume	42
Issue number	1-2
DOIs	https://doi.org/10.1159/000184136
Publication status	Published - 1994

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Expression
Growth factor
Post-transcription
Transcription
Tumor suppressor gene

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1159/000184136

Cite this

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title = "Transforming growth factor-β: Expression in normal and pathological conditions",

abstract = "Expression of the various isoforms of transforming growth factor-β (TGF-β) is differentially controlled both in vivo and in vitro. Characterization of the molecular mechanisms governing expression of TGF-β isoforms now provides a basis for understanding the selective regulation of expression of the TGF-βs by a variety of factors including oncogenes and tumor suppressor genes. In addition to transcriptional control, data suggest that expression of TGF-βs is also regulated posttranscriptionally. Regulation of TGF-βs by steroids and retinoids appears to involve predominantly posttranscriptional mechanisms. Identification of these mechanisms may contribute to the understanding of the regulatory events controlling cellular proliferation and differentiation by TGF-βs and steroids/retinoids.",

keywords = "Expression, Growth factor, Post-transcription, Transcription, Tumor suppressor gene",

author = "Kim, \{Seong Jin\} and David Romeo and \{Do Yoo\}, Young and Keunchil Park",

year = "1994",

doi = "10.1159/000184136",

language = "English",

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journal = "Hormone Research in Paediatrics",

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T2 - Expression in normal and pathological conditions

AU - Kim, Seong Jin

AU - Romeo, David

AU - Do Yoo, Young

AU - Park, Keunchil

PY - 1994

Y1 - 1994

N2 - Expression of the various isoforms of transforming growth factor-β (TGF-β) is differentially controlled both in vivo and in vitro. Characterization of the molecular mechanisms governing expression of TGF-β isoforms now provides a basis for understanding the selective regulation of expression of the TGF-βs by a variety of factors including oncogenes and tumor suppressor genes. In addition to transcriptional control, data suggest that expression of TGF-βs is also regulated posttranscriptionally. Regulation of TGF-βs by steroids and retinoids appears to involve predominantly posttranscriptional mechanisms. Identification of these mechanisms may contribute to the understanding of the regulatory events controlling cellular proliferation and differentiation by TGF-βs and steroids/retinoids.

AB - Expression of the various isoforms of transforming growth factor-β (TGF-β) is differentially controlled both in vivo and in vitro. Characterization of the molecular mechanisms governing expression of TGF-β isoforms now provides a basis for understanding the selective regulation of expression of the TGF-βs by a variety of factors including oncogenes and tumor suppressor genes. In addition to transcriptional control, data suggest that expression of TGF-βs is also regulated posttranscriptionally. Regulation of TGF-βs by steroids and retinoids appears to involve predominantly posttranscriptional mechanisms. Identification of these mechanisms may contribute to the understanding of the regulatory events controlling cellular proliferation and differentiation by TGF-βs and steroids/retinoids.

KW - Expression

KW - Growth factor

KW - Post-transcription

KW - Transcription

KW - Tumor suppressor gene

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U2 - 10.1159/000184136

DO - 10.1159/000184136

M3 - Article

C2 - 7959634

AN - SCOPUS:0028070728

SN - 1663-2818

VL - 42

SP - 5

EP - 8

JO - Hormone Research in Paediatrics

JF - Hormone Research in Paediatrics

IS - 1-2

ER -

Transforming growth factor-β: Expression in normal and pathological conditions

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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