Transgenic fluorescent zebrafish lines that have revolutionized biomedical research

Chong Pyo Choe, Seok Yong Choi, Yun Kee, Min Jung Kim, Seok Hyung Kim, Yoonsung Lee, Hae Chul Park, Hyunju Ro

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)

Abstract

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a vertebrate model organism in more than 40,000 biomedical research studies. Especially useful are zebrafish lines expressing fluorescent proteins in a molecule, intracellular organelle, cell or tissue specific manner because they allow the visualization and tracking of molecules, intracellular organelles, cells or tissues of interest in real time and in vivo. In this review, we summarize representative transgenic fluorescent zebrafish lines that have revolutionized biomedical research on signal transduction, the craniofacial skeletal system, the hematopoietic system, the nervous system, the urogenital system, the digestive system and intracellular organelles.

Original languageEnglish
Article number26
JournalLaboratory Animal Research
Volume37
Issue number1
DOIs
Publication statusPublished - 2021 Dec

Bibliographical note

Publisher Copyright:
© 2021, The Author(s).

Keywords

  • Digestive
  • Fluorescent
  • Hematopoietic
  • Nervous
  • Organelle
  • Signal
  • Skeletal
  • Transgenic
  • Urogenital
  • Zebrafish

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology

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