Transgenic mouse model for breast cancer: Induction of breast cancer in novel oncogene HCCR-2 transgenic mice

Jesang Ko; Seung Min Shin; Young Mi Oh; Youn Soo Lee; Zae Yoong Ryoo; Young Han Lee; Doe Sun Na; Jin Woo Kim

doi:10.1038/sj.onc.1207356

Transgenic mouse model for breast cancer: Induction of breast cancer in novel oncogene HCCR-2 transgenic mice

Jesang Ko, Seung Min Shin, Young Mi Oh, Youn Soo Lee, Zae Yoong Ryoo, Young Han Lee, Doe Sun Na, Jin Woo Kim

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21^WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor.

Original language	English
Pages (from-to)	1950-1953
Number of pages	4
Journal	Oncogene
Volume	23
Issue number	10
DOIs	https://doi.org/10.1038/sj.onc.1207356
Publication status	Published - 2004 Mar 11
Externally published	Yes

Keywords

Breast cancer
HCCR-2
Transgenic mouse
p53

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/sj.onc.1207356

Cite this

@article{1a9e8982677b496aa92bb9c8a75abf79,

title = "Transgenic mouse model for breast cancer: Induction of breast cancer in novel oncogene HCCR-2 transgenic mice",

abstract = "Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor.",

keywords = "Breast cancer, HCCR-2, Transgenic mouse, p53",

author = "Jesang Ko and Shin, {Seung Min} and Oh, {Young Mi} and Lee, {Youn Soo} and Ryoo, {Zae Yoong} and Lee, {Young Han} and Na, {Doe Sun} and Kim, {Jin Woo}",

year = "2004",

month = mar,

day = "11",

doi = "10.1038/sj.onc.1207356",

language = "English",

volume = "23",

pages = "1950--1953",

journal = "Oncogene",

issn = "0950-9232",

publisher = "Springer Nature",

number = "10",

}

TY - JOUR

T1 - Transgenic mouse model for breast cancer

T2 - Induction of breast cancer in novel oncogene HCCR-2 transgenic mice

AU - Ko, Jesang

AU - Shin, Seung Min

AU - Oh, Young Mi

AU - Lee, Youn Soo

AU - Ryoo, Zae Yoong

AU - Lee, Young Han

AU - Na, Doe Sun

AU - Kim, Jin Woo

PY - 2004/3/11

Y1 - 2004/3/11

N2 - Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor.

AB - Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor.

KW - Breast cancer

KW - HCCR-2

KW - Transgenic mouse

KW - p53

UR - http://www.scopus.com/inward/record.url?scp=1842482281&partnerID=8YFLogxK

U2 - 10.1038/sj.onc.1207356

DO - 10.1038/sj.onc.1207356

M3 - Article

C2 - 14691448

AN - SCOPUS:1842482281

SN - 0950-9232

VL - 23

SP - 1950

EP - 1953

JO - Oncogene

JF - Oncogene

IS - 10

ER -

Transgenic mouse model for breast cancer: Induction of breast cancer in novel oncogene HCCR-2 transgenic mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this