TY - JOUR
T1 - Transient changes in brain tissue oxygen in response to modifications of cerebral perfusion pressure
T2 - An observational study
AU - Radolovich, Danila K.
AU - Czosnyka, Marek
AU - Timofeev, Ivan
AU - Lavinio, Andrea
AU - Kim, Dong Joo
AU - Jaeger, Matthias
AU - Hutchinson, Peter
AU - Gupta, Arun
AU - Pickard, John D.
AU - Smielewski, Peter
PY - 2010/1
Y1 - 2010/1
N2 - Background: The relative merits of the mechanisms for the maintenance of brain tissue oxygenation (PbtO2) have been much debated. There is a wealth of studies regarding various factors that may determine the absolute value and changes in PbtO2. However, only a few of them analyzed fast (few minutes) and transient behavior of PbtO2 in response to variations (waves) of intracranial pressure (ICP) and cerebral perfusion pressure (CPP). Methods: This was a retrospective analysis and observational study. PbtO2, arterial blood pressure (ABP), and ICP waveforms were digitally monitored in 23 head-injured patients, admitted to the Neuroscience Critical Care Unit, who were sedated, paralyzed, and ventilated. Computer recordings were retrospectively reviewed. The dynamic changes in PbtO2 in response to transient changes in ABP and ICP were investigated. Results: Several patterns of response to short-lasting arterial hypotension and hypertension, intracranial hypertension, cerebral vasocycling, and cerebral hyperemia were observed and characterized. During the majority of the transient events, PbtO2 generally followed the direction of changes in CPP. Only during episodes of hyperemia, CPP and PbtO2 changed in the opposite direction. Changes in PbtO2 were delayed after dynamic changes in ABP, CPP, and ICP. The CPP-PbtO2 delay during changes provoked by variations in ABP was 35.0 s (range: maximum 827.0 s; minimum 0.0 s) compared with changes induced by variations in ICP of 0.0 s (range: maximum 265.0 s; minimum 0.0 s); the difference was significant at P < 0.0001. Conclusions: PbtO2 is more than a number; it is rather a waveform following rapid changes in ICP and ABP. We show that PbtO2 generally tracks the direction of CPP irrespective of the state of cerebral autoregulation.
AB - Background: The relative merits of the mechanisms for the maintenance of brain tissue oxygenation (PbtO2) have been much debated. There is a wealth of studies regarding various factors that may determine the absolute value and changes in PbtO2. However, only a few of them analyzed fast (few minutes) and transient behavior of PbtO2 in response to variations (waves) of intracranial pressure (ICP) and cerebral perfusion pressure (CPP). Methods: This was a retrospective analysis and observational study. PbtO2, arterial blood pressure (ABP), and ICP waveforms were digitally monitored in 23 head-injured patients, admitted to the Neuroscience Critical Care Unit, who were sedated, paralyzed, and ventilated. Computer recordings were retrospectively reviewed. The dynamic changes in PbtO2 in response to transient changes in ABP and ICP were investigated. Results: Several patterns of response to short-lasting arterial hypotension and hypertension, intracranial hypertension, cerebral vasocycling, and cerebral hyperemia were observed and characterized. During the majority of the transient events, PbtO2 generally followed the direction of changes in CPP. Only during episodes of hyperemia, CPP and PbtO2 changed in the opposite direction. Changes in PbtO2 were delayed after dynamic changes in ABP, CPP, and ICP. The CPP-PbtO2 delay during changes provoked by variations in ABP was 35.0 s (range: maximum 827.0 s; minimum 0.0 s) compared with changes induced by variations in ICP of 0.0 s (range: maximum 265.0 s; minimum 0.0 s); the difference was significant at P < 0.0001. Conclusions: PbtO2 is more than a number; it is rather a waveform following rapid changes in ICP and ABP. We show that PbtO2 generally tracks the direction of CPP irrespective of the state of cerebral autoregulation.
UR - http://www.scopus.com/inward/record.url?scp=74049090852&partnerID=8YFLogxK
U2 - 10.1213/ANE.0b013e3181c0722f
DO - 10.1213/ANE.0b013e3181c0722f
M3 - Article
C2 - 19933525
AN - SCOPUS:74049090852
SN - 0003-2999
VL - 110
SP - 165
EP - 173
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
IS - 1
ER -