TY - JOUR
T1 - Transition-Metal-Free Decarboxylative Coupling Reactions for the Synthesis of Propargyl Alcohols
AU - Irudayanathan, Francis Mariaraj
AU - Kim, Jimin
AU - Song, Kwang Ho
AU - Lee, Sunwoo
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Propargyl alcohols have been directly synthesized by decarboxylative coupling reactions with an alkynyl carboxylic acid and an aldehyde/ketone in the absence of a transition-metal catalyst. When the decarboxylative coupling reaction was conducted with Cs2CO3 in DMSO, the desired propargyl alcohols were formed in good yield. In addition, the reactions with 2,2,2-trifluoroacetophenone and aryl alkynyl carboxylic acids gave trifluoromethylated propargyl alcohols.
AB - Propargyl alcohols have been directly synthesized by decarboxylative coupling reactions with an alkynyl carboxylic acid and an aldehyde/ketone in the absence of a transition-metal catalyst. When the decarboxylative coupling reaction was conducted with Cs2CO3 in DMSO, the desired propargyl alcohols were formed in good yield. In addition, the reactions with 2,2,2-trifluoroacetophenone and aryl alkynyl carboxylic acids gave trifluoromethylated propargyl alcohols.
KW - aldehydes
KW - alkynyl carboxylic acid
KW - decarboxylative coupling
KW - ketones
KW - propargyl alcohol
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U2 - 10.1002/ajoc.201600265
DO - 10.1002/ajoc.201600265
M3 - Article
AN - SCOPUS:84987945039
SN - 2193-5807
VL - 5
SP - 1148
EP - 1154
JO - Asian Journal of Organic Chemistry
JF - Asian Journal of Organic Chemistry
IS - 9
ER -