Transmembrane protein 173 inhibits RANKL-induced osteoclast differentiation

Chung Hyeon Choe, In Sun Park, Jisang Park, Kang Yeol Yu, Hyonseok Jang, Ju Kim, Yong Suk Jang

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Abstract Tmem173 was identified as a growth inhibitor associated with major histocompatibility complex (MHC) class II and a potential stimulator for IFN-β, an innate immune inducer and a negative feedback controller for RANKL-induced osteoclast differentiation of monocytic macrophage cells. In this study, we confirmed that transmembrane protein 173 (Tmem173) overexpression inhibited the expression of osteoclast-specific genes, tartrate-resistant acid phosphatase (TRAP), cathepsin K, and matrix metalloproteinase-9 (MMP-9), as well as bone resorption pit formation in RANKL-treated RAW 264.7 cells. Activation of osteoclast-specific transcription factors, c-Fos and nuclear factor of activated T cells cytoplasmic-1 (NFATc1), and RANKL-induced activation of ERK were also down-regulated by Tmem173 overexpression. Collectively, these results suggest that Tmem173 plays a regulatory role in RANKL-RANK-mediated signaling in osteoclastogenesis.

Original languageEnglish
Article number37040
Pages (from-to)836-841
Number of pages6
JournalFEBS Letters
Issue number7
Publication statusPublished - 2015 Mar 24
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by Basic Science Research Program through the National Research Foundation of Korea ( NRF ) funded by Korean Ministry of Science, ICT & Future Planning ( 2011-0022168 ) and R&D Program funded by the Provincial Government of Jeollabuk-do . Mr. J. Park was supported by the BK21 Plus program in the Department of Bioactive Material Sciences.

Publisher Copyright:
© 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.


  • Osteoclastogenesis
  • RANK ligand
  • Tartrate-resistant acid phosphatase
  • Transmembrane protein 173

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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