TY - JOUR
T1 - Transorbital ultrasonography in acute optic neuritis
T2 - Can it be a supportive diagnostic tool?
AU - Kwon, Ye Ji
AU - Kim, Yoo Hwan
AU - Baek, Seol Hee
AU - Son, Myeong Hun
AU - Lee, Jung Hun
AU - Kim, Byung Jo
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Background: Because of limitations of conventional tools for diagnosing optic neuritis (ON), transorbital ultrasonography (TOUS) was introduced as a promising tool to evaluate the optic nerve. However, studies demonstrating its utility are scarce. Objective: To assess the practical diagnostic value of TOUS in patients with ON along with other diagnostic tools such as visual evoked potential (VEP), MRI, and optical coherence tomography (OCT). Methods: Seventeen patients with first-attack unilateral acute ON were enrolled. Clinical characteristics, visual acuity, TOUS, MRI, VEP, and OCT results were evaluated. Bilateral optic nerves were scanned using TOUS to obtain axial images showing the optic nerve and the disc in the longitudinal plane. Results: TOUS revealed thickening of the optic nerve sheath and optic nerve diameter with sheath on the affected side compared with the unaffected side (p = 0.002 and p = 0.003, respectively). Time since onset of initial symptoms was inversely correlated with optic nerve diameter (ρ = −0.517, p = 0.040) and retinal nerve fiber layer thickness (ρ = −0.831, p < 0.001). Conclusion: TOUS could be a cost-effective tool for morphologically evaluating acute ON showing a significant thickening of the optic nerve and sheath, although only a limited retrobulbar area could be explored.
AB - Background: Because of limitations of conventional tools for diagnosing optic neuritis (ON), transorbital ultrasonography (TOUS) was introduced as a promising tool to evaluate the optic nerve. However, studies demonstrating its utility are scarce. Objective: To assess the practical diagnostic value of TOUS in patients with ON along with other diagnostic tools such as visual evoked potential (VEP), MRI, and optical coherence tomography (OCT). Methods: Seventeen patients with first-attack unilateral acute ON were enrolled. Clinical characteristics, visual acuity, TOUS, MRI, VEP, and OCT results were evaluated. Bilateral optic nerves were scanned using TOUS to obtain axial images showing the optic nerve and the disc in the longitudinal plane. Results: TOUS revealed thickening of the optic nerve sheath and optic nerve diameter with sheath on the affected side compared with the unaffected side (p = 0.002 and p = 0.003, respectively). Time since onset of initial symptoms was inversely correlated with optic nerve diameter (ρ = −0.517, p = 0.040) and retinal nerve fiber layer thickness (ρ = −0.831, p < 0.001). Conclusion: TOUS could be a cost-effective tool for morphologically evaluating acute ON showing a significant thickening of the optic nerve and sheath, although only a limited retrobulbar area could be explored.
KW - Optic coherence tomography
KW - Optic nerve diameter
KW - Optic neuritis
KW - Transorbital ultrasonography
KW - Visual evoked potential
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U2 - 10.1016/j.msard.2019.03.015
DO - 10.1016/j.msard.2019.03.015
M3 - Article
C2 - 30927732
AN - SCOPUS:85063286770
SN - 2211-0348
VL - 31
SP - 54
EP - 58
JO - Multiple Sclerosis and Related Disorders
JF - Multiple Sclerosis and Related Disorders
ER -