Treadmill exercise increases cell proliferation in hippocampal dentate gyrus in alcohol-intoxicated rats

B. K. Yu, B. C. Yoon, S. S. Kim, S. L. Chun, E. H. Kim, K. M. Kim, B. V. Lim, M. H. Jang, J. H. Chung, C. J. Kim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Aim. Effect of treadmill exercise on hippocampal cell proliferation under normal conditions has been well documented; however, this effect under alcohol intoxication conditions is not clarified, yet. In the present study, the effect of treadmill exercise on cell proliferation in the dentate gyrus in alcohol-intoxicated rats was investigated. Methods. Experimental design: comparative investigation on number of 5-bromo-2′-deoxyuridine (BrdU)-positive cells in the dentate gyrus 8 days after commencement. Setting: animal laboratory. Participants: male Sprague-Dawley rats of 5 weeks in age weighing 150±10 g. Intervention: animals were divided into 4 groups: the control-rest group, the control-exercise group, the alcohol-treated-rest group, and the alcohol-treated-exercise group. Animals of the alcohol-treated groups were injected intraperitoneally with alcohol (2 g/kg) once a day for 3 days. All animals were injected BrdU (50 mg/kg) intraperitoneally, and rats of exercise groups were made to run on treadmill for 30 min each day for 5 days following alcohol administration. Measures: mean number of BrdU-positive cells in dentate gyrus was observed via immunohistochemistry. Results. Treadmill exercise significantly increased the number of BrdU-positive cells in the dentate gyrus. Also, treatment with alcohol for 3 days inhibited cell proliferation and treadmill exercise alleviated alcohol-induced inhibition of new cell formation. Conclusion. These results suggest the possibility that treadmill exercise may help in improvement following alcohol-induced brain damage.

Original languageEnglish
Pages (from-to)393-397
Number of pages5
JournalJournal of Sports Medicine and Physical Fitness
Issue number3
Publication statusPublished - 2003 Sept


  • Alcoholism
  • Bromodeoxyuridine
  • Cell proliferation
  • Dentate gyrus
  • Exercise test
  • Immunohistochemistry

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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