Treatment-resistant depression: Understandings on the neurobiological etiology that lead to novel pharmacological treatment options

Eunsoo Won; Byoung Joo Ham; Yong Ku Kim

doi:10.1007/978-981-10-4358-1_7

Treatment-resistant depression: Understandings on the neurobiological etiology that lead to novel pharmacological treatment options

Eunsoo Won, Byoung Joo Ham, Yong Ku Kim

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Treatment-resistant depression (TRD) places a great burden not only to patients but society as a whole. A deep understanding of the neurobiological etiology of TRD will aid us to develop effective treatment strategies for TRD. In this chapter, we will discuss the recent findings on neurobiological mechanisms underlying TRD and corresponding novel pharmacological treatment strategies. Genetics and interactions with environmental factors; alterations in neural substrates, neuroinflammatory conditions, and glutamatergic neurotransmission; and glial cell pathology have been discussed. Anti-inflammatory drugs and ketamine have been suggested as novel treatment agents for TRD. Future studies that investigate the long-term efficacies and safety of such new treatment options in TRD are needed.

Original language	English
Title of host publication	Treatment Resistance in Psychiatry
Subtitle of host publication	Risk Factors, Biology, and Management
Publisher	Springer Singapore
Pages	99-107
Number of pages	9
ISBN (Electronic)	9789811043581
ISBN (Print)	9789811043574
DOIs	https://doi.org/10.1007/978-981-10-4358-1_7
Publication status	Published - 2018 Jan 1

Bibliographical note

Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2019.

Keywords

Neurobiological etiology
Novel pharmacological treatment option
Treatment-resistant depression

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-981-10-4358-1_7

Cite this

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Treatment-resistant depression: Understandings on the neurobiological etiology that lead to novel pharmacological treatment options

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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