Treatment-resistant depression: Understandings on the neurobiological etiology that lead to novel pharmacological treatment options

Eunsoo Won; Byoung Joo Ham; Yong Ku Kim

doi:10.1007/978-981-10-4358-1_7

Treatment-resistant depression: Understandings on the neurobiological etiology that lead to novel pharmacological treatment options

Eunsoo Won, Byoung Joo Ham, Yong Ku Kim

Department of Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Treatment-resistant depression (TRD) places a great burden not only to patients but society as a whole. A deep understanding of the neurobiological etiology of TRD will aid us to develop effective treatment strategies for TRD. In this chapter, we will discuss the recent findings on neurobiological mechanisms underlying TRD and corresponding novel pharmacological treatment strategies. Genetics and interactions with environmental factors; alterations in neural substrates, neuroinflammatory conditions, and glutamatergic neurotransmission; and glial cell pathology have been discussed. Anti-inflammatory drugs and ketamine have been suggested as novel treatment agents for TRD. Future studies that investigate the long-term efficacies and safety of such new treatment options in TRD are needed.

Original language	English
Title of host publication	Treatment Resistance in Psychiatry
Subtitle of host publication	Risk Factors, Biology, and Management
Publisher	Springer Singapore
Pages	99-107
Number of pages	9
ISBN (Electronic)	9789811043581
ISBN (Print)	9789811043574
DOIs	https://doi.org/10.1007/978-981-10-4358-1_7
Publication status	Published - 2018 Jan 1

Keywords

Neurobiological etiology
Novel pharmacological treatment option
Treatment-resistant depression

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1007/978-981-10-4358-1_7

Cite this

@inbook{d707eb7dc8d84194a28deea6a75d48f8,

title = "Treatment-resistant depression: Understandings on the neurobiological etiology that lead to novel pharmacological treatment options",

abstract = "Treatment-resistant depression (TRD) places a great burden not only to patients but society as a whole. A deep understanding of the neurobiological etiology of TRD will aid us to develop effective treatment strategies for TRD. In this chapter, we will discuss the recent findings on neurobiological mechanisms underlying TRD and corresponding novel pharmacological treatment strategies. Genetics and interactions with environmental factors; alterations in neural substrates, neuroinflammatory conditions, and glutamatergic neurotransmission; and glial cell pathology have been discussed. Anti-inflammatory drugs and ketamine have been suggested as novel treatment agents for TRD. Future studies that investigate the long-term efficacies and safety of such new treatment options in TRD are needed.",

keywords = "Neurobiological etiology, Novel pharmacological treatment option, Treatment-resistant depression",

author = "Eunsoo Won and Ham, {Byoung Joo} and Kim, {Yong Ku}",

note = "Publisher Copyright: {\textcopyright} Springer Nature Singapore Pte Ltd. 2019.",

year = "2018",

month = jan,

day = "1",

doi = "10.1007/978-981-10-4358-1_7",

language = "English",

isbn = "9789811043574",

pages = "99--107",

booktitle = "Treatment Resistance in Psychiatry",

publisher = "Springer Singapore",

}

TY - CHAP

T1 - Treatment-resistant depression

T2 - Understandings on the neurobiological etiology that lead to novel pharmacological treatment options

AU - Won, Eunsoo

AU - Ham, Byoung Joo

AU - Kim, Yong Ku

N1 - Publisher Copyright: © Springer Nature Singapore Pte Ltd. 2019.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Treatment-resistant depression (TRD) places a great burden not only to patients but society as a whole. A deep understanding of the neurobiological etiology of TRD will aid us to develop effective treatment strategies for TRD. In this chapter, we will discuss the recent findings on neurobiological mechanisms underlying TRD and corresponding novel pharmacological treatment strategies. Genetics and interactions with environmental factors; alterations in neural substrates, neuroinflammatory conditions, and glutamatergic neurotransmission; and glial cell pathology have been discussed. Anti-inflammatory drugs and ketamine have been suggested as novel treatment agents for TRD. Future studies that investigate the long-term efficacies and safety of such new treatment options in TRD are needed.

AB - Treatment-resistant depression (TRD) places a great burden not only to patients but society as a whole. A deep understanding of the neurobiological etiology of TRD will aid us to develop effective treatment strategies for TRD. In this chapter, we will discuss the recent findings on neurobiological mechanisms underlying TRD and corresponding novel pharmacological treatment strategies. Genetics and interactions with environmental factors; alterations in neural substrates, neuroinflammatory conditions, and glutamatergic neurotransmission; and glial cell pathology have been discussed. Anti-inflammatory drugs and ketamine have been suggested as novel treatment agents for TRD. Future studies that investigate the long-term efficacies and safety of such new treatment options in TRD are needed.

KW - Neurobiological etiology

KW - Novel pharmacological treatment option

KW - Treatment-resistant depression

UR - http://www.scopus.com/inward/record.url?scp=85088476767&partnerID=8YFLogxK

U2 - 10.1007/978-981-10-4358-1_7

DO - 10.1007/978-981-10-4358-1_7

M3 - Chapter

AN - SCOPUS:85088476767

SN - 9789811043574

SP - 99

EP - 107

BT - Treatment Resistance in Psychiatry

PB - Springer Singapore

ER -

Treatment-resistant depression: Understandings on the neurobiological etiology that lead to novel pharmacological treatment options

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this