Treatment-resistant depression: Understandings on the neurobiological etiology that lead to novel pharmacological treatment options

Eunsoo Won, Byoung Joo Ham, Yong Ku Kim

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Treatment-resistant depression (TRD) places a great burden not only to patients but society as a whole. A deep understanding of the neurobiological etiology of TRD will aid us to develop effective treatment strategies for TRD. In this chapter, we will discuss the recent findings on neurobiological mechanisms underlying TRD and corresponding novel pharmacological treatment strategies. Genetics and interactions with environmental factors; alterations in neural substrates, neuroinflammatory conditions, and glutamatergic neurotransmission; and glial cell pathology have been discussed. Anti-inflammatory drugs and ketamine have been suggested as novel treatment agents for TRD. Future studies that investigate the long-term efficacies and safety of such new treatment options in TRD are needed.

    Original languageEnglish
    Title of host publicationTreatment Resistance in Psychiatry
    Subtitle of host publicationRisk Factors, Biology, and Management
    PublisherSpringer Singapore
    Pages99-107
    Number of pages9
    ISBN (Electronic)9789811043581
    ISBN (Print)9789811043574
    DOIs
    Publication statusPublished - 2018 Jan 1

    Bibliographical note

    Publisher Copyright:
    © Springer Nature Singapore Pte Ltd. 2019.

    Keywords

    • Neurobiological etiology
    • Novel pharmacological treatment option
    • Treatment-resistant depression

    ASJC Scopus subject areas

    • General Medicine

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