Triple-conjugated photo-/temperature-/pH-sensitive chitosan with an intelligent response for bioengineering applications

Quang Tuan Che, Korakot Charoensri, Jeong Wook Seo, Minh Hiep Nguyen, Goo Jang, Hojae Bae, Hyun Jin Park

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Hybrid-crosslinked systems, which can be formed using heat and visible light, are significant for improving the stability of hydrogels under physiological conditions. However, several challenges for their practical application remain, such as shrinking under culture medium conditions or the neutral pH in the small intestine. Therefore, a multi-sensitive hydrogel with response to external conditions has been designed and prepared, which could be employed as a biopolymer ink formulation for three-dimensional printing in bioengineering applications. When exposed to body temperature and visible light, the N-succinyl hydroxybutyl methacrylated chitosan (NS-HBC-MA) undergoes a sol-gel phase transition. The NS-HBC-MA hydrogel exhibits pH-responsive swelling, effectively preventing shrinkage at a neutral pH. Furthermore, NS-HBC-MA hydrogel demonstrates excellent biocompatibility and biodegradability. This study demonstrates that the NS-HBC-MA hydrogel has significant potential for various applications, including wound healing, delivery systems, and tissue engineering.

Original languageEnglish
Article number120066
JournalCarbohydrate Polymers
Volume298
DOIs
Publication statusPublished - 2022 Dec 15

Bibliographical note

Funding Information:
This research was supported by Korea University grant and Institute of Biomedical Science & Food Safety, Korea University .

Funding Information:
The authors are grateful for the financial support from the National Research Foundation of Korea (NRF) grant funded by the Korean Government (NRF-2018R1D1A1B05047274).

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

  • 3D printing
  • Chitosan
  • Hydroxybutylation
  • Methacrylation
  • Multi-sensitive hydrogel
  • Succinylation

ASJC Scopus subject areas

  • Materials Chemistry
  • Polymers and Plastics
  • Organic Chemistry

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