Triple-conjugated photo-/temperature-/pH-sensitive chitosan with an intelligent response for bioengineering applications

Quang Tuan Che; Korakot Charoensri; Jeong Wook Seo; Minh Hiep Nguyen; Goo Jang; Hojae Bae; Hyun Jin Park

doi:10.1016/j.carbpol.2022.120066

Triple-conjugated photo-/temperature-/pH-sensitive chitosan with an intelligent response for bioengineering applications

Quang Tuan Che
, Korakot Charoensri
, Jeong Wook Seo
, Minh Hiep Nguyen
, Goo Jang
, Hojae Bae^*
, Hyun Jin Park

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Hybrid-crosslinked systems, which can be formed using heat and visible light, are significant for improving the stability of hydrogels under physiological conditions. However, several challenges for their practical application remain, such as shrinking under culture medium conditions or the neutral pH in the small intestine. Therefore, a multi-sensitive hydrogel with response to external conditions has been designed and prepared, which could be employed as a biopolymer ink formulation for three-dimensional printing in bioengineering applications. When exposed to body temperature and visible light, the N-succinyl hydroxybutyl methacrylated chitosan (NS-HBC-MA) undergoes a sol-gel phase transition. The NS-HBC-MA hydrogel exhibits pH-responsive swelling, effectively preventing shrinkage at a neutral pH. Furthermore, NS-HBC-MA hydrogel demonstrates excellent biocompatibility and biodegradability. This study demonstrates that the NS-HBC-MA hydrogel has significant potential for various applications, including wound healing, delivery systems, and tissue engineering.

Original language	English
Article number	120066
Journal	Carbohydrate Polymers
Volume	298
DOIs	https://doi.org/10.1016/j.carbpol.2022.120066
Publication status	Published - 2022 Dec 15

Bibliographical note

Funding Information:
This research was supported by Korea University grant and Institute of Biomedical Science & Food Safety, Korea University .

Funding Information:
The authors are grateful for the financial support from the National Research Foundation of Korea (NRF) grant funded by the Korean Government (NRF-2018R1D1A1B05047274).

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

3D printing
Chitosan
Hydroxybutylation
Methacrylation
Multi-sensitive hydrogel
Succinylation

ASJC Scopus subject areas

Materials Chemistry
Polymers and Plastics
Organic Chemistry

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10.1016/j.carbpol.2022.120066

Cite this

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title = "Triple-conjugated photo-/temperature-/pH-sensitive chitosan with an intelligent response for bioengineering applications",

abstract = "Hybrid-crosslinked systems, which can be formed using heat and visible light, are significant for improving the stability of hydrogels under physiological conditions. However, several challenges for their practical application remain, such as shrinking under culture medium conditions or the neutral pH in the small intestine. Therefore, a multi-sensitive hydrogel with response to external conditions has been designed and prepared, which could be employed as a biopolymer ink formulation for three-dimensional printing in bioengineering applications. When exposed to body temperature and visible light, the N-succinyl hydroxybutyl methacrylated chitosan (NS-HBC-MA) undergoes a sol-gel phase transition. The NS-HBC-MA hydrogel exhibits pH-responsive swelling, effectively preventing shrinkage at a neutral pH. Furthermore, NS-HBC-MA hydrogel demonstrates excellent biocompatibility and biodegradability. This study demonstrates that the NS-HBC-MA hydrogel has significant potential for various applications, including wound healing, delivery systems, and tissue engineering.",

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AU - Che, Quang Tuan

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AU - Seo, Jeong Wook

AU - Nguyen, Minh Hiep

AU - Jang, Goo

AU - Bae, Hojae

AU - Park, Hyun Jin

N1 - Funding Information: This research was supported by Korea University grant and Institute of Biomedical Science & Food Safety, Korea University . Funding Information: The authors are grateful for the financial support from the National Research Foundation of Korea (NRF) grant funded by the Korean Government (NRF-2018R1D1A1B05047274). Publisher Copyright: © 2022 Elsevier Ltd

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Y1 - 2022/12/15

N2 - Hybrid-crosslinked systems, which can be formed using heat and visible light, are significant for improving the stability of hydrogels under physiological conditions. However, several challenges for their practical application remain, such as shrinking under culture medium conditions or the neutral pH in the small intestine. Therefore, a multi-sensitive hydrogel with response to external conditions has been designed and prepared, which could be employed as a biopolymer ink formulation for three-dimensional printing in bioengineering applications. When exposed to body temperature and visible light, the N-succinyl hydroxybutyl methacrylated chitosan (NS-HBC-MA) undergoes a sol-gel phase transition. The NS-HBC-MA hydrogel exhibits pH-responsive swelling, effectively preventing shrinkage at a neutral pH. Furthermore, NS-HBC-MA hydrogel demonstrates excellent biocompatibility and biodegradability. This study demonstrates that the NS-HBC-MA hydrogel has significant potential for various applications, including wound healing, delivery systems, and tissue engineering.

AB - Hybrid-crosslinked systems, which can be formed using heat and visible light, are significant for improving the stability of hydrogels under physiological conditions. However, several challenges for their practical application remain, such as shrinking under culture medium conditions or the neutral pH in the small intestine. Therefore, a multi-sensitive hydrogel with response to external conditions has been designed and prepared, which could be employed as a biopolymer ink formulation for three-dimensional printing in bioengineering applications. When exposed to body temperature and visible light, the N-succinyl hydroxybutyl methacrylated chitosan (NS-HBC-MA) undergoes a sol-gel phase transition. The NS-HBC-MA hydrogel exhibits pH-responsive swelling, effectively preventing shrinkage at a neutral pH. Furthermore, NS-HBC-MA hydrogel demonstrates excellent biocompatibility and biodegradability. This study demonstrates that the NS-HBC-MA hydrogel has significant potential for various applications, including wound healing, delivery systems, and tissue engineering.

KW - 3D printing

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KW - Methacrylation

KW - Multi-sensitive hydrogel

KW - Succinylation

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ER -

Triple-conjugated photo-/temperature-/pH-sensitive chitosan with an intelligent response for bioengineering applications

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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