Tristetraprolin inhibits the growth of human glioma cells through downregulation of urokinase plasminogen activator/urokinase plasminogen activator receptor mRNAs

Jinhyun Ryu; Nal Ae Yoon; Yeon Kyung Lee; Joo Yeon Jeong; Seokmin Kang; Hyemin Seong; Jungil Choi; Nammi Park; Nayoung Kim; Wha Ja Cho; Sun Ha Paek; Gyeong Jae Cho; Wan Sung Choi; Jae Yong Park; Jeong Woo Park; Sang Soo Kang

doi:10.14348/molcells.2015.2259

Tristetraprolin inhibits the growth of human glioma cells through downregulation of urokinase plasminogen activator/urokinase plasminogen activator receptor mRNAs

Jinhyun Ryu, Nal Ae Yoon, Yeon Kyung Lee, Joo Yeon Jeong, Seokmin Kang, Hyemin Seong, Jungil Choi, Nammi Park, Nayoung Kim, Wha Ja Cho, Sun Ha Paek, Gyeong Jae Cho, Wan Sung Choi, Jae Yong Park, Jeong Woo Park, Sang Soo Kang

School of Biosystem and Biomedical Science

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) play a major role in the infiltrative growth of glioblastoma. Downregulatoion of the uPA and uPAR has been reported to inhibit the growth glioblastoma. Here, we demonstrate that tristetraprolin (TTP) inhibits the growth of U87MG human glioma cells through downregulation of uPA and uPAR. Our results show that expression level of TTP is inversely correlated with those of uPA and uPAR in human glioma cells and tissues. TTP binds to the AU-rich elements within the 3’ untranslated regions of uPA and uPAR and overexpression of TTP decreased the expression of uPA and uPAR through enhancing the degradation of their mRNAs. In addition, overexpression of TTP inhibited the growth and invasion of U87MG cells. Our findings implicate that TTP can be used as a promising therapeutic target to treat human glioma.

Original language	English
Pages (from-to)	156-162
Number of pages	7
Journal	Molecules and cells
Volume	38
Issue number	2
DOIs	https://doi.org/10.14348/molcells.2015.2259
Publication status	Published - 2015 Jan 1

Bibliographical note

Publisher Copyright:
© The Korean Society for Molecular and Cellular Biology. All rights reserved.

Keywords

Glioma
TTP
UPA
UPAR

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.14348/molcells.2015.2259

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Ryu, J., Yoon, N. A., Lee, Y. K., Jeong, J. Y., Kang, S., Seong, H., Choi, J., Park, N., Kim, N., Cho, W. J., Paek, S. H., Cho, G. J., Choi, W. S., Park, J. Y., Park, J. W., & Kang, S. S. (2015). Tristetraprolin inhibits the growth of human glioma cells through downregulation of urokinase plasminogen activator/urokinase plasminogen activator receptor mRNAs. Molecules and cells, 38(2), 156-162. https://doi.org/10.14348/molcells.2015.2259

Ryu, J, Yoon, NA, Lee, YK, Jeong, JY, Kang, S, Seong, H, Choi, J, Park, N, Kim, N, Cho, WJ, Paek, SH, Cho, GJ, Choi, WS, Park, JY, Park, JW & Kang, SS 2015, 'Tristetraprolin inhibits the growth of human glioma cells through downregulation of urokinase plasminogen activator/urokinase plasminogen activator receptor mRNAs', Molecules and cells, vol. 38, no. 2, pp. 156-162. https://doi.org/10.14348/molcells.2015.2259

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abstract = "Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) play a major role in the infiltrative growth of glioblastoma. Downregulatoion of the uPA and uPAR has been reported to inhibit the growth glioblastoma. Here, we demonstrate that tristetraprolin (TTP) inhibits the growth of U87MG human glioma cells through downregulation of uPA and uPAR. Our results show that expression level of TTP is inversely correlated with those of uPA and uPAR in human glioma cells and tissues. TTP binds to the AU-rich elements within the 3{\textquoteright} untranslated regions of uPA and uPAR and overexpression of TTP decreased the expression of uPA and uPAR through enhancing the degradation of their mRNAs. In addition, overexpression of TTP inhibited the growth and invasion of U87MG cells. Our findings implicate that TTP can be used as a promising therapeutic target to treat human glioma.",

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AU - Jeong, Joo Yeon

AU - Kang, Seokmin

AU - Seong, Hyemin

AU - Choi, Jungil

AU - Park, Nammi

AU - Kim, Nayoung

AU - Cho, Wha Ja

AU - Paek, Sun Ha

AU - Cho, Gyeong Jae

AU - Choi, Wan Sung

AU - Park, Jae Yong

AU - Park, Jeong Woo

AU - Kang, Sang Soo

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N2 - Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) play a major role in the infiltrative growth of glioblastoma. Downregulatoion of the uPA and uPAR has been reported to inhibit the growth glioblastoma. Here, we demonstrate that tristetraprolin (TTP) inhibits the growth of U87MG human glioma cells through downregulation of uPA and uPAR. Our results show that expression level of TTP is inversely correlated with those of uPA and uPAR in human glioma cells and tissues. TTP binds to the AU-rich elements within the 3’ untranslated regions of uPA and uPAR and overexpression of TTP decreased the expression of uPA and uPAR through enhancing the degradation of their mRNAs. In addition, overexpression of TTP inhibited the growth and invasion of U87MG cells. Our findings implicate that TTP can be used as a promising therapeutic target to treat human glioma.

AB - Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) play a major role in the infiltrative growth of glioblastoma. Downregulatoion of the uPA and uPAR has been reported to inhibit the growth glioblastoma. Here, we demonstrate that tristetraprolin (TTP) inhibits the growth of U87MG human glioma cells through downregulation of uPA and uPAR. Our results show that expression level of TTP is inversely correlated with those of uPA and uPAR in human glioma cells and tissues. TTP binds to the AU-rich elements within the 3’ untranslated regions of uPA and uPAR and overexpression of TTP decreased the expression of uPA and uPAR through enhancing the degradation of their mRNAs. In addition, overexpression of TTP inhibited the growth and invasion of U87MG cells. Our findings implicate that TTP can be used as a promising therapeutic target to treat human glioma.

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Tristetraprolin inhibits the growth of human glioma cells through downregulation of urokinase plasminogen activator/urokinase plasminogen activator receptor mRNAs

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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