Truxillic acid derivatives act as peroxisome proliferator-activated receptor γ activators

Ramona Steri, Matthias Rupp, Ewgenij Proschak, Timon Schroeter, Heiko Zettl, Katja Hansen, Oliver Schwarz, Lutz Müller-Kuhrt, Klaus Robert Müller, Gisbert Schneider, Manfred Schubert-Zsilavecz

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


In previous studies, we identified a truxillic acid derivative as selective activator of the peroxisome proliferator-activated receptor γ, which is a member of the nuclear receptor family and acts as ligand-activated transcription factor of genes involved in glucose metabolism. Herein we present the structure-activity relationships of 16 truxillic acid derivatives, investigated by a cell-based reporter gene assay guided by molecular docking analysis.

Original languageEnglish
Pages (from-to)2920-2923
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number9
Publication statusPublished - 2010 May 1

Bibliographical note

Funding Information:
We gratefully acknowledge financial support from the Else-Kroener-Fresenius-Stiftung, FIRST (Frankfurt International Research School for Translational Biomedicine) and Lipid Signaling Forschungszentrum Frankfurt (LiFF) . We are grateful to the Chemical Computing Group for a research license of MOE.


  • Molecular docking
  • Nuclear receptors
  • PPARγ
  • Reporter gene assay
  • Structure-activity relationships
  • Truxillic acid derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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