TTF-1, a homeodomain-containing transcription factor, regulates feeding behavior in the rat hypothalamus

Jae Geun Kim; Il Seong Nam-Goong; Chang Ho Yun; Jin Kwon Jeong; Eun Sook Kim; Joong Jean Park; Young Chul Lee; Young Il Kim; Byung Ju Lee

doi:10.1016/j.bbrc.2006.08.147

TTF-1, a homeodomain-containing transcription factor, regulates feeding behavior in the rat hypothalamus

Jae Geun Kim
, Il Seong Nam-Goong
, Chang Ho Yun
, Jin Kwon Jeong
, Eun Sook Kim
, Joong Jean Park
, Young Chul Lee
, Young Il Kim^*
, Byung Ju Lee

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

TTF-1 is a member of the NKx family of homeodomain genes, and is required for morphogenesis and fetal diencephalon development. Our previous studies have shown that TTF-1 expression is maintained in some regions of the postnatal rat brain and transactivates the gene expression of several neuropeptides. In this study, a potential role for TTF-1 in the regulation of feeding behavior was identified. Immunohistochemical analysis showed that TTF-1 is present in several hypothalamic nuclei of the adult rat brain involved in the control of feeding behavior. Food deprivation for two days markedly increased the hypothalamic levels of TTF-1 mRNA and protein. Intracerebroventricular administration of an antisense TTF-1 oligodeoxynucleotide significantly decreased TTF-1 protein abundance in the hypothalamus. This TTF-1 decrease was followed by a significant decrease in neuropeptide Y mRNA content and an increase in proopiomelanocortin mRNA content, and in turn resulted in a decrease of the animal's food intake and body weight. These results suggest a novel role for TTF-1 in the regulation of feeding behavior in the rat hypothalamus.

Original language	English
Pages (from-to)	969-975
Number of pages	7
Journal	Biochemical and biophysical research communications
Volume	349
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2006.08.147
Publication status	Published - 2006 Oct 27
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the Korea Research Foundation Grant (KRF-2002-070-C00068). J.G.K. and C.H.Y. were partially supported by Brain Korea 21 Grant (C119).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Food intake
Hypothalamus
Neuropeptide Y
Obesity
Proopiomelanocortin
TTF-1

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2006.08.147

Cite this

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title = "TTF-1, a homeodomain-containing transcription factor, regulates feeding behavior in the rat hypothalamus",

abstract = "TTF-1 is a member of the NKx family of homeodomain genes, and is required for morphogenesis and fetal diencephalon development. Our previous studies have shown that TTF-1 expression is maintained in some regions of the postnatal rat brain and transactivates the gene expression of several neuropeptides. In this study, a potential role for TTF-1 in the regulation of feeding behavior was identified. Immunohistochemical analysis showed that TTF-1 is present in several hypothalamic nuclei of the adult rat brain involved in the control of feeding behavior. Food deprivation for two days markedly increased the hypothalamic levels of TTF-1 mRNA and protein. Intracerebroventricular administration of an antisense TTF-1 oligodeoxynucleotide significantly decreased TTF-1 protein abundance in the hypothalamus. This TTF-1 decrease was followed by a significant decrease in neuropeptide Y mRNA content and an increase in proopiomelanocortin mRNA content, and in turn resulted in a decrease of the animal's food intake and body weight. These results suggest a novel role for TTF-1 in the regulation of feeding behavior in the rat hypothalamus.",

keywords = "Food intake, Hypothalamus, Neuropeptide Y, Obesity, Proopiomelanocortin, TTF-1",

author = "Kim, \{Jae Geun\} and Nam-Goong, \{Il Seong\} and Yun, \{Chang Ho\} and Jeong, \{Jin Kwon\} and Kim, \{Eun Sook\} and Park, \{Joong Jean\} and Lee, \{Young Chul\} and Kim, \{Young Il\} and Lee, \{Byung Ju\}",

note = "Funding Information: This work was supported by the Korea Research Foundation Grant (KRF-2002-070-C00068). J.G.K. and C.H.Y. were partially supported by Brain Korea 21 Grant (C119).",

year = "2006",

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doi = "10.1016/j.bbrc.2006.08.147",

language = "English",

volume = "349",

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journal = "Biochemical and biophysical research communications",

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AU - Kim, Jae Geun

AU - Nam-Goong, Il Seong

AU - Yun, Chang Ho

AU - Jeong, Jin Kwon

AU - Kim, Eun Sook

AU - Park, Joong Jean

AU - Lee, Young Chul

AU - Kim, Young Il

AU - Lee, Byung Ju

N1 - Funding Information: This work was supported by the Korea Research Foundation Grant (KRF-2002-070-C00068). J.G.K. and C.H.Y. were partially supported by Brain Korea 21 Grant (C119).

PY - 2006/10/27

Y1 - 2006/10/27

N2 - TTF-1 is a member of the NKx family of homeodomain genes, and is required for morphogenesis and fetal diencephalon development. Our previous studies have shown that TTF-1 expression is maintained in some regions of the postnatal rat brain and transactivates the gene expression of several neuropeptides. In this study, a potential role for TTF-1 in the regulation of feeding behavior was identified. Immunohistochemical analysis showed that TTF-1 is present in several hypothalamic nuclei of the adult rat brain involved in the control of feeding behavior. Food deprivation for two days markedly increased the hypothalamic levels of TTF-1 mRNA and protein. Intracerebroventricular administration of an antisense TTF-1 oligodeoxynucleotide significantly decreased TTF-1 protein abundance in the hypothalamus. This TTF-1 decrease was followed by a significant decrease in neuropeptide Y mRNA content and an increase in proopiomelanocortin mRNA content, and in turn resulted in a decrease of the animal's food intake and body weight. These results suggest a novel role for TTF-1 in the regulation of feeding behavior in the rat hypothalamus.

AB - TTF-1 is a member of the NKx family of homeodomain genes, and is required for morphogenesis and fetal diencephalon development. Our previous studies have shown that TTF-1 expression is maintained in some regions of the postnatal rat brain and transactivates the gene expression of several neuropeptides. In this study, a potential role for TTF-1 in the regulation of feeding behavior was identified. Immunohistochemical analysis showed that TTF-1 is present in several hypothalamic nuclei of the adult rat brain involved in the control of feeding behavior. Food deprivation for two days markedly increased the hypothalamic levels of TTF-1 mRNA and protein. Intracerebroventricular administration of an antisense TTF-1 oligodeoxynucleotide significantly decreased TTF-1 protein abundance in the hypothalamus. This TTF-1 decrease was followed by a significant decrease in neuropeptide Y mRNA content and an increase in proopiomelanocortin mRNA content, and in turn resulted in a decrease of the animal's food intake and body weight. These results suggest a novel role for TTF-1 in the regulation of feeding behavior in the rat hypothalamus.

KW - Food intake

KW - Hypothalamus

KW - Neuropeptide Y

KW - Obesity

KW - Proopiomelanocortin

KW - TTF-1

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DO - 10.1016/j.bbrc.2006.08.147

M3 - Article

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JO - Biochemical and biophysical research communications

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IS - 3

ER -

TTF-1, a homeodomain-containing transcription factor, regulates feeding behavior in the rat hypothalamus

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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