Abstract
We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.
Original language | English |
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Pages (from-to) | 1223-1232 |
Number of pages | 10 |
Journal | Genomics |
Volume | 112 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2020 Mar |
Bibliographical note
Publisher Copyright:© 2019
Keywords
- Lung adenocarcinoma
- Lung cancer
- Mendelian randomization
- Pathway analysis
- Tuberculosis
ASJC Scopus subject areas
- Genetics