Tumor microenvironmental factors have prognostic significances in advanced gastric cancer

Bokyung Ahn; Yang Seok Chae; Chul Hwan Kim; Youngseok Lee; Jeong Hyeon Lee; Joo Young Kim

doi:10.1111/apm.12889

Tumor microenvironmental factors have prognostic significances in advanced gastric cancer

Bokyung Ahn, Yang Seok Chae, Chul Hwan Kim, Youngseok Lee, Jeong Hyeon Lee, Joo Young Kim

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11 Citations (Scopus)

Abstract

Tumor microenvironment is important in the progression and survival of cancer cells. We evaluated the prognostic significance of tumor stroma percentage (TSP), Klintrup–Mäkinen (KM) grade, which reflects the density of inflammatory cells of the tumor, and Glasgow microenvironment score (GMS), a combination of TSP and KM grade, in advanced gastric cancers. A total of 196 pT3 and pT4 gastric cancers were histologically evaluated using TSP, KM grade, and GMS. These were correlated with other clinicopathologic factors including patients’ survival. High TSP (78 cases), low KM grade (124 cases), and higher GMS (score 0, 72 cases; 1, 53 cases; and 2, 71 cases) were correlated with poor differentiation, diffuse type, presence of lymphovascular invasion, perineural invasion, and lymph node metastasis. High TSP was significantly correlated with low KM grade (p < 0.001). High TSP (HR, 3.079, 95% CI, 1.612–5.883, p = 0.001), low KM grade (3.201, 1.774–5.776, p < 0.001), and higher GMS (12.274, 3.684–40.895, p < 0.001) were independent poor prognostic factors. TSP, KM grade, and GMS are significantly associated with clinicopathologic behavior and patients’ survival. Assessing these factors is a feasible and cost-effective way to identify tumor microenvironment with different biological features and prognosis of gastric cancer patients.

Original language	English
Pages (from-to)	814-821
Number of pages	8
Journal	APMIS
Volume	126
Issue number	10
DOIs	https://doi.org/10.1111/apm.12889
Publication status	Published - 2018 Oct

Bibliographical note

Funding Information:
This research was supported by a grant of Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. O1700371). A total of 196 surgically resected pT3 and pT4 gastric adenocarcinomas were retrieved from the Department of Pathology, Korea University Anam hospital, from January 2009 to December 2012. We excluded pT1 and pT2 cases because tumor stromal components were not clearly defined in the invasive front of the tumor in mucosa, submucosa, and proper muscle, as in the subserosa or serosa. Patients who received neoadjuvant chemotherapy were excluded. Clinical data including age, sex, survival months, and survival status were reviewed. Pathologic data including tumor location, Borrmann type, Lauren classification, tumor size, grade, pT category, lymphovascular invasion (LVI), perineural invasion (PNI), lymph node (LN) status, distant metastasis, and resection marginal status were reviewed.

Funding Information:
This research was supported by a grant of Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. O1700371).

Publisher Copyright:
© 2018 APMIS. Published by John Wiley & Sons Ltd

Keywords

Gastric cancer
Glasgow microenvironment score
Klintrup–Mäkinen grade
tumor microenvironment
tumor stroma percentage

ASJC Scopus subject areas

Pathology and Forensic Medicine
Immunology and Allergy
Microbiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/apm.12889

Cite this

@article{6382160b19e34cab980ee6cc48537075,

title = "Tumor microenvironmental factors have prognostic significances in advanced gastric cancer",

abstract = "Tumor microenvironment is important in the progression and survival of cancer cells. We evaluated the prognostic significance of tumor stroma percentage (TSP), Klintrup–M{\"a}kinen (KM) grade, which reflects the density of inflammatory cells of the tumor, and Glasgow microenvironment score (GMS), a combination of TSP and KM grade, in advanced gastric cancers. A total of 196 pT3 and pT4 gastric cancers were histologically evaluated using TSP, KM grade, and GMS. These were correlated with other clinicopathologic factors including patients{\textquoteright} survival. High TSP (78 cases), low KM grade (124 cases), and higher GMS (score 0, 72 cases; 1, 53 cases; and 2, 71 cases) were correlated with poor differentiation, diffuse type, presence of lymphovascular invasion, perineural invasion, and lymph node metastasis. High TSP was significantly correlated with low KM grade (p < 0.001). High TSP (HR, 3.079, 95% CI, 1.612–5.883, p = 0.001), low KM grade (3.201, 1.774–5.776, p < 0.001), and higher GMS (12.274, 3.684–40.895, p < 0.001) were independent poor prognostic factors. TSP, KM grade, and GMS are significantly associated with clinicopathologic behavior and patients{\textquoteright} survival. Assessing these factors is a feasible and cost-effective way to identify tumor microenvironment with different biological features and prognosis of gastric cancer patients.",

keywords = "Gastric cancer, Glasgow microenvironment score, Klintrup–M{\"a}kinen grade, tumor microenvironment, tumor stroma percentage",

author = "Bokyung Ahn and Chae, {Yang Seok} and Kim, {Chul Hwan} and Youngseok Lee and Lee, {Jeong Hyeon} and Kim, {Joo Young}",

note = "Funding Information: This research was supported by a grant of Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. O1700371). A total of 196 surgically resected pT3 and pT4 gastric adenocarcinomas were retrieved from the Department of Pathology, Korea University Anam hospital, from January 2009 to December 2012. We excluded pT1 and pT2 cases because tumor stromal components were not clearly defined in the invasive front of the tumor in mucosa, submucosa, and proper muscle, as in the subserosa or serosa. Patients who received neoadjuvant chemotherapy were excluded. Clinical data including age, sex, survival months, and survival status were reviewed. Pathologic data including tumor location, Borrmann type, Lauren classification, tumor size, grade, pT category, lymphovascular invasion (LVI), perineural invasion (PNI), lymph node (LN) status, distant metastasis, and resection marginal status were reviewed. Funding Information: This research was supported by a grant of Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. O1700371). Publisher Copyright: {\textcopyright} 2018 APMIS. Published by John Wiley & Sons Ltd",

year = "2018",

month = oct,

doi = "10.1111/apm.12889",

language = "English",

volume = "126",

pages = "814--821",

journal = "APMIS",

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T1 - Tumor microenvironmental factors have prognostic significances in advanced gastric cancer

AU - Ahn, Bokyung

AU - Chae, Yang Seok

AU - Kim, Chul Hwan

AU - Lee, Youngseok

AU - Lee, Jeong Hyeon

AU - Kim, Joo Young

N1 - Funding Information: This research was supported by a grant of Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. O1700371). A total of 196 surgically resected pT3 and pT4 gastric adenocarcinomas were retrieved from the Department of Pathology, Korea University Anam hospital, from January 2009 to December 2012. We excluded pT1 and pT2 cases because tumor stromal components were not clearly defined in the invasive front of the tumor in mucosa, submucosa, and proper muscle, as in the subserosa or serosa. Patients who received neoadjuvant chemotherapy were excluded. Clinical data including age, sex, survival months, and survival status were reviewed. Pathologic data including tumor location, Borrmann type, Lauren classification, tumor size, grade, pT category, lymphovascular invasion (LVI), perineural invasion (PNI), lymph node (LN) status, distant metastasis, and resection marginal status were reviewed. Funding Information: This research was supported by a grant of Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. O1700371). Publisher Copyright: © 2018 APMIS. Published by John Wiley & Sons Ltd

PY - 2018/10

Y1 - 2018/10

N2 - Tumor microenvironment is important in the progression and survival of cancer cells. We evaluated the prognostic significance of tumor stroma percentage (TSP), Klintrup–Mäkinen (KM) grade, which reflects the density of inflammatory cells of the tumor, and Glasgow microenvironment score (GMS), a combination of TSP and KM grade, in advanced gastric cancers. A total of 196 pT3 and pT4 gastric cancers were histologically evaluated using TSP, KM grade, and GMS. These were correlated with other clinicopathologic factors including patients’ survival. High TSP (78 cases), low KM grade (124 cases), and higher GMS (score 0, 72 cases; 1, 53 cases; and 2, 71 cases) were correlated with poor differentiation, diffuse type, presence of lymphovascular invasion, perineural invasion, and lymph node metastasis. High TSP was significantly correlated with low KM grade (p < 0.001). High TSP (HR, 3.079, 95% CI, 1.612–5.883, p = 0.001), low KM grade (3.201, 1.774–5.776, p < 0.001), and higher GMS (12.274, 3.684–40.895, p < 0.001) were independent poor prognostic factors. TSP, KM grade, and GMS are significantly associated with clinicopathologic behavior and patients’ survival. Assessing these factors is a feasible and cost-effective way to identify tumor microenvironment with different biological features and prognosis of gastric cancer patients.

AB - Tumor microenvironment is important in the progression and survival of cancer cells. We evaluated the prognostic significance of tumor stroma percentage (TSP), Klintrup–Mäkinen (KM) grade, which reflects the density of inflammatory cells of the tumor, and Glasgow microenvironment score (GMS), a combination of TSP and KM grade, in advanced gastric cancers. A total of 196 pT3 and pT4 gastric cancers were histologically evaluated using TSP, KM grade, and GMS. These were correlated with other clinicopathologic factors including patients’ survival. High TSP (78 cases), low KM grade (124 cases), and higher GMS (score 0, 72 cases; 1, 53 cases; and 2, 71 cases) were correlated with poor differentiation, diffuse type, presence of lymphovascular invasion, perineural invasion, and lymph node metastasis. High TSP was significantly correlated with low KM grade (p < 0.001). High TSP (HR, 3.079, 95% CI, 1.612–5.883, p = 0.001), low KM grade (3.201, 1.774–5.776, p < 0.001), and higher GMS (12.274, 3.684–40.895, p < 0.001) were independent poor prognostic factors. TSP, KM grade, and GMS are significantly associated with clinicopathologic behavior and patients’ survival. Assessing these factors is a feasible and cost-effective way to identify tumor microenvironment with different biological features and prognosis of gastric cancer patients.

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KW - Glasgow microenvironment score

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Tumor microenvironmental factors have prognostic significances in advanced gastric cancer

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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