Tumor necrosis factor-α and interleukin-1β increases CTRP1 expression in adipose tissue

Kun yong Kim, Hwa Young Kim, Jae Hyeong Kim, Chul Ho Lee, Do Hyung Kim, Young Ho Lee, Seung Hyun Han, Jong Seok Lim, Dae Ho Cho, Myeong Sok Lee, Sukjoon Yoon, Keun Il Kim, Do Young Yoon, Young Yang

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)


CTRP1, a member of the CTRP superfamily, consists of an N-terminal signal peptide sequence followed by a variable region, a collagen repeat domain, and a C-terminal globular domain. CTRP1 is expressed at high levels in adipose tissues of LPS-stimulated Sprague-Dawley rats. The LPS-induced increase in CTRP1 gene expression was found to be mediated by TNF-α and IL-1β. Also, a high level of expression of CTRP1 mRNA was observed in adipose tissues of Zucker diabetic fatty (fa/fa) rats, compared to Sprague-Dawley rats in the absence of LPS stimulation. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.

Original languageEnglish
Pages (from-to)3953-3960
Number of pages8
JournalFEBS Letters
Issue number16
Publication statusPublished - 2006 Jul 10
Externally publishedYes


  • Adipokine
  • CTRP
  • Proinflammatory cytokines

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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