Tumor necrosis factor-α and interleukin-1β increases CTRP1 expression in adipose tissue

Kun yong Kim; Hwa Young Kim; Jae Hyeong Kim; Chul Ho Lee; Do Hyung Kim; Young Ho Lee; Seung Hyun Han; Jong Seok Lim; Dae Ho Cho; Myeong Sok Lee; Sukjoon Yoon; Keun Il Kim; Do Young Yoon; Young Yang

doi:10.1016/j.febslet.2006.06.034

Tumor necrosis factor-α and interleukin-1β increases CTRP1 expression in adipose tissue

Kun yong Kim, Hwa Young Kim, Jae Hyeong Kim, Chul Ho Lee, Do Hyung Kim, Young Ho Lee, Seung Hyun Han, Jong Seok Lim, Dae Ho Cho, Myeong Sok Lee, Sukjoon Yoon, Keun Il Kim, Do Young Yoon, Young Yang

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

CTRP1, a member of the CTRP superfamily, consists of an N-terminal signal peptide sequence followed by a variable region, a collagen repeat domain, and a C-terminal globular domain. CTRP1 is expressed at high levels in adipose tissues of LPS-stimulated Sprague-Dawley rats. The LPS-induced increase in CTRP1 gene expression was found to be mediated by TNF-α and IL-1β. Also, a high level of expression of CTRP1 mRNA was observed in adipose tissues of Zucker diabetic fatty (fa/fa) rats, compared to Sprague-Dawley rats in the absence of LPS stimulation. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.

Original language	English
Pages (from-to)	3953-3960
Number of pages	8
Journal	FEBS Letters
Volume	580
Issue number	16
DOIs	https://doi.org/10.1016/j.febslet.2006.06.034
Publication status	Published - 2006 Jul 10
Externally published	Yes

Keywords

Adipokine
CTRP
Proinflammatory cytokines

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.febslet.2006.06.034

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@article{340365ab4b24474aa6a2a98eb4baf9ab,

title = "Tumor necrosis factor-α and interleukin-1β increases CTRP1 expression in adipose tissue",

abstract = "CTRP1, a member of the CTRP superfamily, consists of an N-terminal signal peptide sequence followed by a variable region, a collagen repeat domain, and a C-terminal globular domain. CTRP1 is expressed at high levels in adipose tissues of LPS-stimulated Sprague-Dawley rats. The LPS-induced increase in CTRP1 gene expression was found to be mediated by TNF-α and IL-1β. Also, a high level of expression of CTRP1 mRNA was observed in adipose tissues of Zucker diabetic fatty (fa/fa) rats, compared to Sprague-Dawley rats in the absence of LPS stimulation. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.",

keywords = "Adipokine, CTRP, Proinflammatory cytokines",

author = "Kim, {Kun yong} and Kim, {Hwa Young} and Kim, {Jae Hyeong} and Lee, {Chul Ho} and Kim, {Do Hyung} and Lee, {Young Ho} and Han, {Seung Hyun} and Lim, {Jong Seok} and Cho, {Dae Ho} and Lee, {Myeong Sok} and Sukjoon Yoon and Kim, {Keun Il} and Yoon, {Do Young} and Young Yang",

note = "Funding Information: This work was supported by Grant R01-2004-000-10648-0 from the Basic Research Program of the Korea Science and Engineering Foundation and the SRC Program of KOSEF (R11-2005-017-01002-0).",

year = "2006",

month = jul,

day = "10",

doi = "10.1016/j.febslet.2006.06.034",

language = "English",

volume = "580",

pages = "3953--3960",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "16",

}

TY - JOUR

T1 - Tumor necrosis factor-α and interleukin-1β increases CTRP1 expression in adipose tissue

AU - Kim, Kun yong

AU - Kim, Hwa Young

AU - Kim, Jae Hyeong

AU - Lee, Chul Ho

AU - Kim, Do Hyung

AU - Lee, Young Ho

AU - Han, Seung Hyun

AU - Lim, Jong Seok

AU - Cho, Dae Ho

AU - Lee, Myeong Sok

AU - Yoon, Sukjoon

AU - Kim, Keun Il

AU - Yoon, Do Young

AU - Yang, Young

N1 - Funding Information: This work was supported by Grant R01-2004-000-10648-0 from the Basic Research Program of the Korea Science and Engineering Foundation and the SRC Program of KOSEF (R11-2005-017-01002-0).

PY - 2006/7/10

Y1 - 2006/7/10

N2 - CTRP1, a member of the CTRP superfamily, consists of an N-terminal signal peptide sequence followed by a variable region, a collagen repeat domain, and a C-terminal globular domain. CTRP1 is expressed at high levels in adipose tissues of LPS-stimulated Sprague-Dawley rats. The LPS-induced increase in CTRP1 gene expression was found to be mediated by TNF-α and IL-1β. Also, a high level of expression of CTRP1 mRNA was observed in adipose tissues of Zucker diabetic fatty (fa/fa) rats, compared to Sprague-Dawley rats in the absence of LPS stimulation. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.

AB - CTRP1, a member of the CTRP superfamily, consists of an N-terminal signal peptide sequence followed by a variable region, a collagen repeat domain, and a C-terminal globular domain. CTRP1 is expressed at high levels in adipose tissues of LPS-stimulated Sprague-Dawley rats. The LPS-induced increase in CTRP1 gene expression was found to be mediated by TNF-α and IL-1β. Also, a high level of expression of CTRP1 mRNA was observed in adipose tissues of Zucker diabetic fatty (fa/fa) rats, compared to Sprague-Dawley rats in the absence of LPS stimulation. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.

KW - Adipokine

KW - CTRP

KW - Proinflammatory cytokines

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U2 - 10.1016/j.febslet.2006.06.034

DO - 10.1016/j.febslet.2006.06.034

M3 - Article

C2 - 16806199

AN - SCOPUS:33745386896

SN - 0014-5793

VL - 580

SP - 3953

EP - 3960

JO - FEBS Letters

JF - FEBS Letters

IS - 16

ER -

Tumor necrosis factor-α and interleukin-1β increases CTRP1 expression in adipose tissue

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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