Tumor-targeting gold particles for dual computed tomography/optical cancer imaging

In Cheol Sun, Dae Kyung Eun, Heebeom Koo, Chang Yong Ko, Han Sung Kim, Dong Kee Yi, Kuiwon Choi, Ick Chan Kwon, Kwangmeyung Kim, Cheol Hee Ahn

    Research output: Contribution to journalArticlepeer-review

    117 Citations (Scopus)

    Abstract

    Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X-ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes.

    Original languageEnglish
    Pages (from-to)9348-9351
    Number of pages4
    JournalAngewandte Chemie - International Edition
    Volume50
    Issue number40
    DOIs
    Publication statusPublished - 2011 Sept 26

    Keywords

    • computed tomography
    • gold
    • imaging agents
    • nanoparticles

    ASJC Scopus subject areas

    • Catalysis
    • General Chemistry

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