Tumor-targeting multi-functional nanoparticles for theragnosis: New paradigm for cancer therapy

Ju Hee Ryu, Heebeom Koo, In Cheol Sun, Soon Hong Yuk, Kuiwon Choi, Kwangmeyung Kim, Ick Chan Kwon

Research output: Contribution to journalReview articlepeer-review

197 Citations (Scopus)


Theragnostic nanoparticles (NPs) contain diagnostic and therapeutic functions in one integrated system, enabling diagnosis, therapy, and monitoring of therapeutic response at the same time. For diagnostic function, theragnostic NPs require the inclusion of noninvasive imaging modalities. Among them, optical imaging has various advantages including sensitivity, real-time and convenient use, and non-ionization safety, which make it the leading technique for theragnostic NPs. For therapeutic function, theragnostic NPs have been applied to chemotherapy, photodynamic therapy, siRNA therapy and photothermal therapy. In this review, we present a recent progress reported in the development and applications of theragnostic NPs for cancer therapy. More specifically, we will focus on theragnostic NPs related with optical imaging, highlighting promising strategies based on optical imaging techniques.

Original languageEnglish
Pages (from-to)1447-1458
Number of pages12
JournalAdvanced Drug Delivery Reviews
Issue number13
Publication statusPublished - 2012 Oct
Externally publishedYes

Bibliographical note

Funding Information:
This work is supported by the M.D.-Ph.D. Program ( 2010-0019863 , 2010-0019864 ), the Global Research Laboratory Project of MEST , and the Intramural Research Program (Theragnosis) of KIST .

Copyright 2013 Elsevier B.V., All rights reserved.


  • Cancer
  • Chemotherapy
  • Molecular imaging
  • Nanomedicine
  • Optical imaging
  • Personalized medicine
  • Photodynamic therapy
  • Photothermal therapy
  • SiRNA therapy
  • Theragnosis

ASJC Scopus subject areas

  • Pharmaceutical Science


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