Tuning polymeric and drug properties in a drug eluting stent: A numerical study

Jahed Naghipoor; José A. Ferreira; Paula de Oliveira; Timon Rabczuk

doi:10.1016/j.apm.2016.04.001

Tuning polymeric and drug properties in a drug eluting stent: A numerical study

Jahed Naghipoor, José A. Ferreira, Paula de Oliveira, Timon Rabczuk

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A two dimensional coupled nonlinear non-Fickian model for drug release from a biodegradable drug eluting stent into the arterial wall is studied. The influence of porosity and degradation of the polymer as well as the dissolution rate of the drug are analyzed. Numerical simulations that illustrate the kind of dependence of drug profiles on these properties are included.

Original language	English
Pages (from-to)	8067-8086
Number of pages	20
Journal	Applied Mathematical Modelling
Volume	40
Issue number	17-18
DOIs	https://doi.org/10.1016/j.apm.2016.04.001
Publication status	Published - 2016 Sept 1

Bibliographical note

Funding Information:
This work is supported by Alexander von Humboldt Foundation (AvH) under the Georg Forster Research Fellowship (HERMES), Institute of Structural Mechanics (ISM), Bauhaus-Universität Weimar as well as the Centro de Matemática da Universidade de Coimbra (CMUC), funded by the European Regional Development Fund through the program COMPETE and by the Portuguese Government through the FCT under the project, PEst-C/MAT/UI0324/2013.

Publisher Copyright:
© 2016 Elsevier Inc.

Keywords

Dissolved drug
Domain decomposition methods
Drug eluting stent
Numerical simulation

ASJC Scopus subject areas

Modelling and Simulation
Applied Mathematics

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10.1016/j.apm.2016.04.001

Cite this

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title = "Tuning polymeric and drug properties in a drug eluting stent: A numerical study",

abstract = "A two dimensional coupled nonlinear non-Fickian model for drug release from a biodegradable drug eluting stent into the arterial wall is studied. The influence of porosity and degradation of the polymer as well as the dissolution rate of the drug are analyzed. Numerical simulations that illustrate the kind of dependence of drug profiles on these properties are included.",

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AU - Oliveira, Paula de

AU - Rabczuk, Timon

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Tuning polymeric and drug properties in a drug eluting stent: A numerical study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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