Tuning polymeric and drug properties in a drug eluting stent: A numerical study

Jahed Naghipoor; José A. Ferreira; Paula de Oliveira; Timon Rabczuk

doi:10.1016/j.apm.2016.04.001

Tuning polymeric and drug properties in a drug eluting stent: A numerical study

Jahed Naghipoor^*
, José A. Ferreira
, Paula de Oliveira
, Timon Rabczuk

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A two dimensional coupled nonlinear non-Fickian model for drug release from a biodegradable drug eluting stent into the arterial wall is studied. The influence of porosity and degradation of the polymer as well as the dissolution rate of the drug are analyzed. Numerical simulations that illustrate the kind of dependence of drug profiles on these properties are included.

Original language	English
Pages (from-to)	8067-8086
Number of pages	20
Journal	Applied Mathematical Modelling
Volume	40
Issue number	17-18
DOIs	https://doi.org/10.1016/j.apm.2016.04.001
Publication status	Published - 2016 Sept 1

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc.

Keywords

Dissolved drug
Domain decomposition methods
Drug eluting stent
Numerical simulation

ASJC Scopus subject areas

Modelling and Simulation
Applied Mathematics

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10.1016/j.apm.2016.04.001

Cite this

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title = "Tuning polymeric and drug properties in a drug eluting stent: A numerical study",

abstract = "A two dimensional coupled nonlinear non-Fickian model for drug release from a biodegradable drug eluting stent into the arterial wall is studied. The influence of porosity and degradation of the polymer as well as the dissolution rate of the drug are analyzed. Numerical simulations that illustrate the kind of dependence of drug profiles on these properties are included.",

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T2 - A numerical study

AU - Naghipoor, Jahed

AU - Ferreira, José A.

AU - Oliveira, Paula de

AU - Rabczuk, Timon

PY - 2016/9/1

Y1 - 2016/9/1

N2 - A two dimensional coupled nonlinear non-Fickian model for drug release from a biodegradable drug eluting stent into the arterial wall is studied. The influence of porosity and degradation of the polymer as well as the dissolution rate of the drug are analyzed. Numerical simulations that illustrate the kind of dependence of drug profiles on these properties are included.

AB - A two dimensional coupled nonlinear non-Fickian model for drug release from a biodegradable drug eluting stent into the arterial wall is studied. The influence of porosity and degradation of the polymer as well as the dissolution rate of the drug are analyzed. Numerical simulations that illustrate the kind of dependence of drug profiles on these properties are included.

KW - Dissolved drug

KW - Domain decomposition methods

KW - Drug eluting stent

KW - Numerical simulation

UR - https://www.scopus.com/pages/publications/84975505415

U2 - 10.1016/j.apm.2016.04.001

DO - 10.1016/j.apm.2016.04.001

M3 - Article

AN - SCOPUS:84975505415

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VL - 40

SP - 8067

EP - 8086

JO - Applied Mathematical Modelling

JF - Applied Mathematical Modelling

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ER -

Tuning polymeric and drug properties in a drug eluting stent: A numerical study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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