Two Cases of Multiple Cutaneous Squamous Cell Carcinomas

The causes of the cutaneous squamous cell carcinomas (SCCs) are diverse, and when the multiple SCCs are found at the same time, not only the treatment of the lesions but also the consideration of the causes are important. Then, when actinic keratoses coexist with SCCs on the sun-exposed area at the same time, the most probable cause of the SCC is the ultraviolet light-induced skin damage. But when the multiple SCCs are developed on the sun-protected area, one must consider the patient's history of exposure to arsenic. We report two patients having multiple SCCs of the skin. One is considered to be associated with the previous arsenic exposure and the other with chronic sun damage and the resultant actinic keratoses.