Two-photon fluorescent probes for intracellular free zinc ions in living tissue

Hwan Myung Kim; Mun Sik Seo; Myoung Jin An; Jin Hee Hong; Yu Shun Tian; Joon Ho Choi; Ohyun Kwon; Kyoung J. Lee; Bong Rae Cho

doi:10.1002/anie.200800929

Two-photon fluorescent probes for intracellular free zinc ions in living tissue

Hwan Myung Kim, Mun Sik Seo, Myoung Jin An, Jin Hee Hong, Yu Shun Tian, Joon Ho Choi, Ohyun Kwon, Kyoung J. Lee, Bong Rae Cho

Research output: Contribution to journal › Article › peer-review

124 Citations (Scopus)

Abstract

The living image: The efficient two-photon probes AZn1 and AZn2 (see picture for rat brain tissue) show 24-to 52-fold two-photon excited fluorescence enhancement in response to Zn²⁺. They can selectively detect intracellular free Zn²⁺ ions in live cells and in living tissues at a depth of 80-150 mm without interference from other metal ions and the membrane-bound probes. (Chemical Equation Presented)

Original language	English
Pages (from-to)	5167-5170
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	28
DOIs	https://doi.org/10.1002/anie.200800929
Publication status	Published - 2008 Jun 27

Keywords

Fluorescent probes
Imaging agents
Living tissue
Two-photon microscopy
Zinc

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200800929

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title = "Two-photon fluorescent probes for intracellular free zinc ions in living tissue",

abstract = "The living image: The efficient two-photon probes AZn1 and AZn2 (see picture for rat brain tissue) show 24-to 52-fold two-photon excited fluorescence enhancement in response to Zn2+. They can selectively detect intracellular free Zn2+ ions in live cells and in living tissues at a depth of 80-150 mm without interference from other metal ions and the membrane-bound probes. (Chemical Equation Presented)",

keywords = "Fluorescent probes, Imaging agents, Living tissue, Two-photon microscopy, Zinc",

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AU - Kim, Hwan Myung

AU - Seo, Mun Sik

AU - An, Myoung Jin

AU - Hong, Jin Hee

AU - Tian, Yu Shun

AU - Choi, Joon Ho

AU - Kwon, Ohyun

AU - Lee, Kyoung J.

AU - Cho, Bong Rae

PY - 2008/6/27

Y1 - 2008/6/27

N2 - The living image: The efficient two-photon probes AZn1 and AZn2 (see picture for rat brain tissue) show 24-to 52-fold two-photon excited fluorescence enhancement in response to Zn2+. They can selectively detect intracellular free Zn2+ ions in live cells and in living tissues at a depth of 80-150 mm without interference from other metal ions and the membrane-bound probes. (Chemical Equation Presented)

AB - The living image: The efficient two-photon probes AZn1 and AZn2 (see picture for rat brain tissue) show 24-to 52-fold two-photon excited fluorescence enhancement in response to Zn2+. They can selectively detect intracellular free Zn2+ ions in live cells and in living tissues at a depth of 80-150 mm without interference from other metal ions and the membrane-bound probes. (Chemical Equation Presented)

KW - Fluorescent probes

KW - Imaging agents

KW - Living tissue

KW - Two-photon microscopy

KW - Zinc

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 28

ER -

Two-photon fluorescent probes for intracellular free zinc ions in living tissue

Abstract

Keywords

ASJC Scopus subject areas

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