Two-photon fluorescent probes for intracellular free zinc ions in living tissue

Hwan Myung Kim, Mun Sik Seo, Myoung Jin An, Jin Hee Hong, Yu Shun Tian, Joon Ho Choi, Ohyun Kwon, Kyoung J. Lee, Bong Rae Cho

Research output: Contribution to journalArticlepeer-review

125 Citations (Scopus)


The living image: The efficient two-photon probes AZn1 and AZn2 (see picture for rat brain tissue) show 24-to 52-fold two-photon excited fluorescence enhancement in response to Zn2+. They can selectively detect intracellular free Zn2+ ions in live cells and in living tissues at a depth of 80-150 mm without interference from other metal ions and the membrane-bound probes. (Chemical Equation Presented)

Original languageEnglish
Pages (from-to)5167-5170
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number28
Publication statusPublished - 2008 Jun 27


  • Fluorescent probes
  • Imaging agents
  • Living tissue
  • Two-photon microscopy
  • Zinc

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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