Abstract
Two-photon microscopy (TPM) has become an indispensible tool in biology and medicine owing to the capability of imaging the intact tissue for a long period of time. To make it a versatile tool in biology, a variety of two-photon probes for specific applications are needed. In this context, many research groups are developing two-photon probes for various applications. In this Focus Review, we summarize recent results on model studies and selected examples of two-photon probes that can detect intracellular free metal ions in live cells and tissues to provide a guideline for the design of useful two-photon probes for various in vivo imaging applications. In search for metals: In this Focus Review, recent model studies and selected examples are described of two-photon probes that can detect intracellular free metal ions in live cells and tissues to provide a guideline for the design of useful two-photon probes for various in vivo imaging applications.
| Original language | English |
|---|---|
| Pages (from-to) | 58-69 |
| Number of pages | 12 |
| Journal | Chemistry - An Asian Journal |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2011 Jan 3 |
Keywords
- fluorescent probes
- in vivo imaging
- metal ions
- nonlinear spectroscopy
- two-photon microscopy
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry