Two-photon fluorescent turn-on probe for lipid rafts in live cell and tissue

Myung Kim Hwan, Ha Jeong Byeong, Ju Yong Hyon, Jin An Myoung, Sik Seo Mun, Hee Hong Jin, Kyoung J. Lee, Hoon Kim Chul, Taiha Joo, Seok Cheol Hong, Rae Cho Bong

Research output: Contribution to journalArticlepeer-review

125 Citations (Scopus)


We report a new two-photon fluorescence turn-on probe 6-[(E)-3-oxo-1-dodecenyl]-2-[N-methyl-N-(carboxymethyl)amino]naphthalene (CL2) that is designed specifically for visualizing lipid rafts in living cells and tissues. This probe emits much brighter two-photon excited fluorescence in lipid rafts than in non-raft domains and allows direct visualization of the lipid rafts in the live cells and pyramidal neuron layer of the CA1 region at a depth of 100-250 μm in live tissues using two-photon microscopy.

Original languageEnglish
Pages (from-to)4246-4247
Number of pages2
JournalJournal of the American Chemical Society
Issue number13
Publication statusPublished - 2008 Apr 2

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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