Abstract
Novel two-photon (TP) probes were developed for lysosomes (PLT-yellow) and mitochondria (BMT-blue and PMT-yellow). These probes emitted strong TP-excited fluorescence in cells at widely separated wavelength regions and displayed high organelle selectivity, good cell permeability, low cytotoxicity, and pH insensitivity. The BMT-blue and PLT-yellow probes could be utilized to detect lysosomes and mitochondria simultaneously in live tissues by using dual-color two-photon microscopy, with minimum interference from each other.
Original language | English |
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Pages (from-to) | 2240-2249 |
Number of pages | 10 |
Journal | Chemistry - An Asian Journal |
Volume | 10 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2015 Oct 1 |
Bibliographical note
Publisher Copyright:© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keywords
- fluorescent probes
- imaging agents
- lysosomes
- mitochondria
- two photon
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry