Two-Photon Probes for Lysosomes and Mitochondria: Simultaneous Detection of Lysosomes and Mitochondria in Live Tissues by Dual-Color Two-Photon Microscopy Imaging

Chang Su Lim, Seung Taek Hong, Seong Shick Ryu, Dong Eun Kang, Bong Rae Cho

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)

    Abstract

    Novel two-photon (TP) probes were developed for lysosomes (PLT-yellow) and mitochondria (BMT-blue and PMT-yellow). These probes emitted strong TP-excited fluorescence in cells at widely separated wavelength regions and displayed high organelle selectivity, good cell permeability, low cytotoxicity, and pH insensitivity. The BMT-blue and PLT-yellow probes could be utilized to detect lysosomes and mitochondria simultaneously in live tissues by using dual-color two-photon microscopy, with minimum interference from each other.

    Original languageEnglish
    Pages (from-to)2240-2249
    Number of pages10
    JournalChemistry - An Asian Journal
    Volume10
    Issue number10
    DOIs
    Publication statusPublished - 2015 Oct 1

    Bibliographical note

    Publisher Copyright:
    © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

    Keywords

    • fluorescent probes
    • imaging agents
    • lysosomes
    • mitochondria
    • two photon

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry

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