Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model

Ji Won Park; Yong Jae Kim; In Sik Shin; Ok Kyoung Kwon; Ju Mi Hong; Na Rae Shin; Sei Ryang Oh; Un Hwan Ha; Jae Hong Kim; Kyung Seop Ahn

doi:10.1093/infdis/jiw278

Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model

Ji Won Park, Yong Jae Kim, In Sik Shin, Ok Kyoung Kwon, Ju Mi Hong, Na Rae Shin, Sei Ryang Oh, Un Hwan Ha, Jae Hong Kim, Kyung Seop Ahn

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The type III secretion system (T3SS) in Pseudomonas aeruginosa has been linked to severe disease and poor clinical outcomes in animal and human studies. We aimed to investigate whether the ExoS and ExoT effector proteins of P. aeruginosa affect the expression of matrix metalloproteinase 12 (MMP-12) and MMP-13 via nuclear factor κB (NF-κB) signaling pathways.

Original language	English
Pages (from-to)	962-969
Number of pages	8
Journal	Journal of Infectious Diseases
Volume	214
Issue number	6
DOIs	https://doi.org/10.1093/infdis/jiw278
Publication status	Published - 2016 Sept 15

Bibliographical note

Funding Information:
This work was supported by the International Broad Material Research Center, funded by the Ministry of Health and Welfare (HI14C1277) and awarded to the Korea Research Institute of Bioscience and Biotechnology Research Initiative Program (KGM 1221622) of the Republic of Korea.

Publisher Copyright:
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.

Keywords

MMP-13
NCI-H292
NF-κB
Pneumonia
Pseudomonas aeruginosa
matrix metalloproteinase (MMP)-12
type III secretion system

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/infdis/jiw278

Fingerprint

Dive into the research topics of 'Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model'. Together they form a unique fingerprint.

Cite this

Park, J. W., Kim, Y. J., Shin, I. S., Kwon, O. K., Hong, J. M., Shin, N. R., Oh, S. R., Ha, U. H., Kim, J. H., & Ahn, K. S. (2016). Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model. Journal of Infectious Diseases, 214(6), 962-969. https://doi.org/10.1093/infdis/jiw278

Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model. / Park, Ji Won; Kim, Yong Jae; Shin, In Sik et al.
In: Journal of Infectious Diseases, Vol. 214, No. 6, 15.09.2016, p. 962-969.

Research output: Contribution to journal › Article › peer-review

Park, JW, Kim, YJ, Shin, IS, Kwon, OK, Hong, JM, Shin, NR, Oh, SR, Ha, UH, Kim, JH & Ahn, KS 2016, 'Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model', Journal of Infectious Diseases, vol. 214, no. 6, pp. 962-969. https://doi.org/10.1093/infdis/jiw278

@article{bff466af63f14d4b8fe07a73a3acc140,

title = "Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model",

abstract = "The type III secretion system (T3SS) in Pseudomonas aeruginosa has been linked to severe disease and poor clinical outcomes in animal and human studies. We aimed to investigate whether the ExoS and ExoT effector proteins of P. aeruginosa affect the expression of matrix metalloproteinase 12 (MMP-12) and MMP-13 via nuclear factor κB (NF-κB) signaling pathways.",

keywords = "MMP-13, NCI-H292, NF-κB, Pneumonia, Pseudomonas aeruginosa, matrix metalloproteinase (MMP)-12, type III secretion system",

author = "Park, {Ji Won} and Kim, {Yong Jae} and Shin, {In Sik} and Kwon, {Ok Kyoung} and Hong, {Ju Mi} and Shin, {Na Rae} and Oh, {Sei Ryang} and Ha, {Un Hwan} and Kim, {Jae Hong} and Ahn, {Kyung Seop}",

note = "Funding Information: This work was supported by the International Broad Material Research Center, funded by the Ministry of Health and Welfare (HI14C1277) and awarded to the Korea Research Institute of Bioscience and Biotechnology Research Initiative Program (KGM 1221622) of the Republic of Korea. Publisher Copyright: {\textcopyright} The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.",

year = "2016",

month = sep,

day = "15",

doi = "10.1093/infdis/jiw278",

language = "English",

volume = "214",

pages = "962--969",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "6",

}

TY - JOUR

T1 - Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model

AU - Park, Ji Won

AU - Kim, Yong Jae

AU - Shin, In Sik

AU - Kwon, Ok Kyoung

AU - Hong, Ju Mi

AU - Shin, Na Rae

AU - Oh, Sei Ryang

AU - Ha, Un Hwan

AU - Kim, Jae Hong

AU - Ahn, Kyung Seop

N1 - Funding Information: This work was supported by the International Broad Material Research Center, funded by the Ministry of Health and Welfare (HI14C1277) and awarded to the Korea Research Institute of Bioscience and Biotechnology Research Initiative Program (KGM 1221622) of the Republic of Korea. Publisher Copyright: © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.

PY - 2016/9/15

Y1 - 2016/9/15

N2 - The type III secretion system (T3SS) in Pseudomonas aeruginosa has been linked to severe disease and poor clinical outcomes in animal and human studies. We aimed to investigate whether the ExoS and ExoT effector proteins of P. aeruginosa affect the expression of matrix metalloproteinase 12 (MMP-12) and MMP-13 via nuclear factor κB (NF-κB) signaling pathways.

AB - The type III secretion system (T3SS) in Pseudomonas aeruginosa has been linked to severe disease and poor clinical outcomes in animal and human studies. We aimed to investigate whether the ExoS and ExoT effector proteins of P. aeruginosa affect the expression of matrix metalloproteinase 12 (MMP-12) and MMP-13 via nuclear factor κB (NF-κB) signaling pathways.

KW - MMP-13

KW - NCI-H292

KW - NF-κB

KW - Pneumonia

KW - Pseudomonas aeruginosa

KW - matrix metalloproteinase (MMP)-12

KW - type III secretion system

UR - http://www.scopus.com/inward/record.url?scp=84985027740&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiw278

DO - 10.1093/infdis/jiw278

M3 - Article

C2 - 27377745

AN - SCOPUS:84985027740

SN - 0022-1899

VL - 214

SP - 962

EP - 969

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 6

ER -

Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this