Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κb Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model

Ji Won Park, Yong Jae Kim, In Sik Shin, Ok Kyoung Kwon, Ju Mi Hong, Na Rae Shin, Sei Ryang Oh, Un Hwan Ha, Jae Hong Kim, Kyung Seop Ahn

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The type III secretion system (T3SS) in Pseudomonas aeruginosa has been linked to severe disease and poor clinical outcomes in animal and human studies. We aimed to investigate whether the ExoS and ExoT effector proteins of P. aeruginosa affect the expression of matrix metalloproteinase 12 (MMP-12) and MMP-13 via nuclear factor κB (NF-κB) signaling pathways.

Original languageEnglish
Pages (from-to)962-969
Number of pages8
JournalJournal of Infectious Diseases
Volume214
Issue number6
DOIs
Publication statusPublished - 2016 Sept 15

Bibliographical note

Funding Information:
This work was supported by the International Broad Material Research Center, funded by the Ministry of Health and Welfare (HI14C1277) and awarded to the Korea Research Institute of Bioscience and Biotechnology Research Initiative Program (KGM 1221622) of the Republic of Korea.

Publisher Copyright:
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.

Keywords

  • MMP-13
  • NCI-H292
  • NF-κB
  • Pneumonia
  • Pseudomonas aeruginosa
  • matrix metalloproteinase (MMP)-12
  • type III secretion system

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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