Tyrosyltyrosylcysteine-Directed Synthesis of Chiral Cobalt Oxide Nanoparticles and Peptide Conformation Analysis

Hyeohn Kim; Kyeong Mi Bang; Heonjin Ha; Nam Heon Cho; Seok Daniel Namgung; Sang Won Im; Kang Hee Cho; Ryeong Myeong Kim; Won Il Choi; Yae Chan Lim; Ji Yeon Shin; Hyun Kyu Song; Nak Kyoon Kim; Ki Tae Nam

doi:10.1021/acsnano.0c07655

Tyrosyltyrosylcysteine-Directed Synthesis of Chiral Cobalt Oxide Nanoparticles and Peptide Conformation Analysis

Hyeohn Kim, Kyeong Mi Bang, Heonjin Ha, Nam Heon Cho, Seok Daniel Namgung, Sang Won Im, Kang Hee Cho, Ryeong Myeong Kim, Won Il Choi, Yae Chan Lim, Ji Yeon Shin, Hyun Kyu Song, Nak Kyoon Kim, Ki Tae Nam

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Chiral inorganic nanomaterials have revealed opportunities in various fields owing to their strong light-matter interactions. In particular, chiral metal oxide nanomaterials that can control light and biochemical reactions have been highlighted due to their catalytic activity and biocompatibility. In this study, we present the synthesis of chiral cobalt oxide nanoparticles with a g-factor of 0.01 in the UV-visible region using l-and d-Tyr-Tyr-Cys ligands. The conformation of the Tyr-Tyr-Cys peptide on the nanoparticle surfaces was identified by 2D NMR spectroscopy analysis. In addition, the sequence effect of Tyr-Tyr-Cys developing chiral nanoparticles was analyzed. The revealed peptide structure, along with the experimental results, demonstrate the important role of the thiol group and carboxyl group of the Tyr-Tyr-Cys ligand in chirality evolution. Importantly, due to the magnetic properties of chiral cobalt oxide nanoparticles and their strong absorption in the UV region, the circular dichroism (CD) responses can be dramatically modulated under an external magnetic field.

Original language	English
Pages (from-to)	979-988
Number of pages	10
Journal	ACS nano
Volume	15
Issue number	1
DOIs	https://doi.org/10.1021/acsnano.0c07655
Publication status	Published - 2021 Jan 26

Bibliographical note

Funding Information:
This research was supported by Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by Ministry of Science and ICT (NRF-2017M3D1A1039377), the KIST-SNU Joint Research Lab project (2 V06170) under the KIST Institutional Program funded by the Korean government (Ministry of Science, ICT & Future Planning), and the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (NRF-2017R1A2B3012003). This work was supported by LG Display under the LGD-SNU Incubation Program. K.T.N. appreciates the support from Institute of Engineering Research, Research Institute of Advanced Materials (RIAM), and Soft Foundry at Seoul National University.

Publisher Copyright:
© 2021 American Chemical Society. All rights reserved.

Keywords

NMR
Tyr-Tyr-Cys
chirality
cobalt oxide nanoparticle
magnetic circular dichroism
peptide ligand

ASJC Scopus subject areas

General Materials Science
General Engineering
General Physics and Astronomy

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10.1021/acsnano.0c07655

Cite this

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title = "Tyrosyltyrosylcysteine-Directed Synthesis of Chiral Cobalt Oxide Nanoparticles and Peptide Conformation Analysis",

abstract = "Chiral inorganic nanomaterials have revealed opportunities in various fields owing to their strong light-matter interactions. In particular, chiral metal oxide nanomaterials that can control light and biochemical reactions have been highlighted due to their catalytic activity and biocompatibility. In this study, we present the synthesis of chiral cobalt oxide nanoparticles with a g-factor of 0.01 in the UV-visible region using l-and d-Tyr-Tyr-Cys ligands. The conformation of the Tyr-Tyr-Cys peptide on the nanoparticle surfaces was identified by 2D NMR spectroscopy analysis. In addition, the sequence effect of Tyr-Tyr-Cys developing chiral nanoparticles was analyzed. The revealed peptide structure, along with the experimental results, demonstrate the important role of the thiol group and carboxyl group of the Tyr-Tyr-Cys ligand in chirality evolution. Importantly, due to the magnetic properties of chiral cobalt oxide nanoparticles and their strong absorption in the UV region, the circular dichroism (CD) responses can be dramatically modulated under an external magnetic field.",

keywords = "NMR, Tyr-Tyr-Cys, chirality, cobalt oxide nanoparticle, magnetic circular dichroism, peptide ligand",

author = "Hyeohn Kim and Bang, {Kyeong Mi} and Heonjin Ha and Cho, {Nam Heon} and Namgung, {Seok Daniel} and Im, {Sang Won} and Cho, {Kang Hee} and Kim, {Ryeong Myeong} and Choi, {Won Il} and Lim, {Yae Chan} and Shin, {Ji Yeon} and Song, {Hyun Kyu} and Kim, {Nak Kyoon} and Nam, {Ki Tae}",

note = "Funding Information: This research was supported by Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by Ministry of Science and ICT (NRF-2017M3D1A1039377), the KIST-SNU Joint Research Lab project (2 V06170) under the KIST Institutional Program funded by the Korean government (Ministry of Science, ICT & Future Planning), and the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (NRF-2017R1A2B3012003). This work was supported by LG Display under the LGD-SNU Incubation Program. K.T.N. appreciates the support from Institute of Engineering Research, Research Institute of Advanced Materials (RIAM), and Soft Foundry at Seoul National University. Publisher Copyright: {\textcopyright} 2021 American Chemical Society. All rights reserved.",

year = "2021",

month = jan,

day = "26",

doi = "10.1021/acsnano.0c07655",

language = "English",

volume = "15",

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AU - Kim, Hyeohn

AU - Bang, Kyeong Mi

AU - Ha, Heonjin

AU - Cho, Nam Heon

AU - Namgung, Seok Daniel

AU - Im, Sang Won

AU - Cho, Kang Hee

AU - Kim, Ryeong Myeong

AU - Choi, Won Il

AU - Lim, Yae Chan

AU - Shin, Ji Yeon

AU - Song, Hyun Kyu

AU - Kim, Nak Kyoon

AU - Nam, Ki Tae

N1 - Funding Information: This research was supported by Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by Ministry of Science and ICT (NRF-2017M3D1A1039377), the KIST-SNU Joint Research Lab project (2 V06170) under the KIST Institutional Program funded by the Korean government (Ministry of Science, ICT & Future Planning), and the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (NRF-2017R1A2B3012003). This work was supported by LG Display under the LGD-SNU Incubation Program. K.T.N. appreciates the support from Institute of Engineering Research, Research Institute of Advanced Materials (RIAM), and Soft Foundry at Seoul National University. Publisher Copyright: © 2021 American Chemical Society. All rights reserved.

PY - 2021/1/26

Y1 - 2021/1/26

N2 - Chiral inorganic nanomaterials have revealed opportunities in various fields owing to their strong light-matter interactions. In particular, chiral metal oxide nanomaterials that can control light and biochemical reactions have been highlighted due to their catalytic activity and biocompatibility. In this study, we present the synthesis of chiral cobalt oxide nanoparticles with a g-factor of 0.01 in the UV-visible region using l-and d-Tyr-Tyr-Cys ligands. The conformation of the Tyr-Tyr-Cys peptide on the nanoparticle surfaces was identified by 2D NMR spectroscopy analysis. In addition, the sequence effect of Tyr-Tyr-Cys developing chiral nanoparticles was analyzed. The revealed peptide structure, along with the experimental results, demonstrate the important role of the thiol group and carboxyl group of the Tyr-Tyr-Cys ligand in chirality evolution. Importantly, due to the magnetic properties of chiral cobalt oxide nanoparticles and their strong absorption in the UV region, the circular dichroism (CD) responses can be dramatically modulated under an external magnetic field.

AB - Chiral inorganic nanomaterials have revealed opportunities in various fields owing to their strong light-matter interactions. In particular, chiral metal oxide nanomaterials that can control light and biochemical reactions have been highlighted due to their catalytic activity and biocompatibility. In this study, we present the synthesis of chiral cobalt oxide nanoparticles with a g-factor of 0.01 in the UV-visible region using l-and d-Tyr-Tyr-Cys ligands. The conformation of the Tyr-Tyr-Cys peptide on the nanoparticle surfaces was identified by 2D NMR spectroscopy analysis. In addition, the sequence effect of Tyr-Tyr-Cys developing chiral nanoparticles was analyzed. The revealed peptide structure, along with the experimental results, demonstrate the important role of the thiol group and carboxyl group of the Tyr-Tyr-Cys ligand in chirality evolution. Importantly, due to the magnetic properties of chiral cobalt oxide nanoparticles and their strong absorption in the UV region, the circular dichroism (CD) responses can be dramatically modulated under an external magnetic field.

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ER -

Tyrosyltyrosylcysteine-Directed Synthesis of Chiral Cobalt Oxide Nanoparticles and Peptide Conformation Analysis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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