Ultra-sensitive direct detection of silver ions via Kelvin probe force microscopy

Jinsung Park, Sangmyung Lee, Kuewhan Jang, Sungsoo Na

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Nanotoxicity is receiving great importance due to its potential impact on human health and environment and due to rapid development in the field of nanoscale research and industry. Herein, we report the Kelvin probe force microscope (KPPM)-based nanotoxicity material detection using surface potential difference. In general, it is difficult to measure the size of ion (Ag+) using a conventional atomic force microscope (AFM) because of the limited resolution. In this study, we have demonstrated that KPFM is capable of ultra-sensitive detection of silver ion with silver specific DNA by a single droplet. Furthermore, the measured surface potentials for Ag+ and DNA binding enable the detection performance for a practical sample that is general drinking water. Remarkably, the KPFM based silver ion detection enables an insight into the coordination chemistry, which plays an important role in early detection of toxicity. This implies that KPFM based detection system opens a new avenue for water testing sensor.

Original languageEnglish
Pages (from-to)299-304
Number of pages6
JournalBiosensors and Bioelectronics
Publication statusPublished - 2014 Oct 15

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) under Grant nos. NRF-2013-044213 , ERC-2007-0056094 , and NRF-2013058102 which is funded by the Ministry of Science, ICT & Future Planning.


  • DNA-metal interaction
  • Kelvin probe force microscope
  • Silver ion
  • Single droplet
  • Surface potential

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry


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