Ultrasensitive optical biodiagnostic methods using metallic nanoparticles

So Youn Shim, Dong Kwon Lim, Jwa Min Nam

Research output: Contribution to journalReview articlepeer-review

65 Citations (Scopus)


Dramatic progress has been made over the recent decade in the applications of metallic nanoparticles in the field of biomolecule detection. The useful physical and chemical properties (e.g., availability of various synthetic methods of size- and shape-controlled nanoparticles, size- and shape-dependent optical properties, availability of various surface chemistries and biocompatibility) of metallic nanoparticles have brought development to the ultrasensitive detection of biomolecules at the attomolar level and this sensitivity enables the diagnosis of otherwise undetectable biomarkers of many fatal diseases, including Alzheimer's disease. Furthermore, coupled with the strong physical properties and biocompatible nature of gold nanoparticles in in vivo conditions, the scope of applications for these particles have been broadened into the field of in vivo imaging, such as X-ray contrasting agents, and also cellular tracking. Here, we review synthetic methods and optical properties of metallic nanoparticles and their use in ultrasensitive, in vitro and in vivo biodiagnostic methods.

Original languageEnglish
Pages (from-to)215-232
Number of pages18
Issue number2
Publication statusPublished - 2008 Apr
Externally publishedYes


  • Bio-barcode assay
  • Colorimetric detection
  • DNA detection
  • Gold nanoparticles
  • In vivo imaging
  • Magnetic nanoparticles
  • Metallic nanoparticles
  • Metallic nanowire
  • Protein detection
  • Silver amplification
  • Silver nanoparticles
  • Surface plasmon resonance
  • Ultrasensitive detection

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • General Materials Science


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