Abstract
The design of cancer-targeting particles with precisely tuned physicochemical properties may enhance the delivery of therapeutics and access to pharmacological targets. However, a molecular-level understanding of the interactions driving the fate of nanomedicine in biological systems remains elusive. Here, we show that ultrasmall (<10nm in diameter) poly(ethylene glycol)-coated silica nanoparticles, functionalized with melanoma-targeting peptides, can induce a form of programmed cell death known as ferroptosis in starved cancer cells and cancer-bearing mice. Tumour xenografts in mice intravenously injected with nanoparticles using a high-dose multiple injection scheme exhibit reduced growth or regression, in a manner that is reversed by the pharmacological inhibitor of ferroptosis, liproxstatin-1. These data demonstrate that ferroptosis can be targeted by ultrasmall silica nanoparticles and may have therapeutic potential.
Original language | English |
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Pages (from-to) | 977-985 |
Number of pages | 9 |
Journal | Nature Nanotechnology |
Volume | 11 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2016 Nov 1 |
Externally published | Yes |
Bibliographical note
Funding Information:This study was funded by grants from the National Institutes of Health (R01GM111350 to M.O.; 1R01CA161280-01A1 to M.B. and U.W.; 1U54 CA199081-01 to M.B. and U.W.; R01GM113013 and R01CA166413 to X.J.; Sloan Kettering Institute Core Grant P30 CA008748CCSG and the Benjamin Friedman Research Fund to M.O.). Peptide synthesis was conducted by the University of Missouri Structural Biology Core.
ASJC Scopus subject areas
- Bioengineering
- Atomic and Molecular Physics, and Optics
- Biomedical Engineering
- General Materials Science
- Condensed Matter Physics
- Electrical and Electronic Engineering